Senior Scientist/Group Leader, Protein Analytics - Morgan Hill, CA | Biospace
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Senior Scientist/Group Leader, Protein Analytics

Aragen Bioscience, Inc.

Location:
Morgan Hill, CA
Posted Date:
6/8/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Masters Degree
Areas of Expertise Desired:
Protein, Senior Scientist,

Job Description

Aragen Bioscience is a value-added contract research organization that offers a diverse range of services related to preclinical development of biotherapeutics and diagnostics. Our client base includes some of the biggest names in biotechnology, as well as some of the most innovative new ventures in the industry. Aragen is dedicated to advancing human health as both an expert partner, and a reliable service provider. Aragen employees thrive on challenge and enjoy the opportunity to work on diverse projects in a fast-paced environment.  Joining Aragen offers the opportunity for personal and professional growth.

The successful candidate will work in a collaborative setting within the Protein Sciences Unit leading protein analytic and formulation efforts and will have a strong working knowledge of protein expression and purification. The position will be accountable for the execution, documentation and presentation of a suite of bioanalytical assays to support protein characterization and integration into antibody discovery and cell line development campaigns.  The candidate should have experience in capillary electrophoresis techniques (IEF, SDS, and N-glycan analysis), HPLC techniques, and Mass Spectrometry.  An essential feature for this position is experience in thermostability assessment of proteins by DSC/DSF for formulation and shelf life studies. Significant experience with data analysis, presentation, and technical report writing is required. The candidate must be self-motivated, have a demonstrated ability to multiplex high priority projects and work independently.

POSITION DUTIES AND RESPONSIBILTIES:

•   Build and lead a protein analytics team
•   Performance, documentation, and presentation of protein analytical techniques such as ceSDS, ceIEF, N-glycan analysis, HPLC/UPLC techniques (aSEC, RP, NP and IEX).
•   Performance, documentation, and presentation of mass spectrometry experimentation including accurate mass determination, PTMs and peptide mapping.
•   Performance, documentation, and presentation of protein stability (DSC/DSF), formulation, shelf life and similar studies.
•   Functional analysis of proteins by enzyme assays, binding assays, and other assays as required.
•   Engagement with past, current and prospective clients to understand their protein analytical needs and discussion scientific workplans.
•   Maintain detailed and accurate laboratory notebook records.
•   Be an engaged team member providing input into experiment design in a constructive manner
•   Participate in the maintenance of laboratory equipment, laboratory supplies, and a clean working environment.
•   Participation in department meetings, including internal scientific presentations
•   Other duties as assigned.

Requirements


•   Education: A Ph.D. in Biology, Biochemistry, or similar field and at least 5 years of post-graduate experience in a professional environment.  A masters degree with significant relevant experience and knowledge will be considered.
•   Intuitive knowledge and technical excellence in protein analytics with a keen interest in using biophysical and functional analysis to confirm protein integrity.
•   Ability to drive strategies and problem solve for formulation and shelf life experimentation for a diverse range of proteins from many different customers.
•   Good oral and written communication skills and the ability to work well as a member of a team are imperative.
•   Proficiency in Word, Excel, PowerPoint and data analysis are expected.