Nurix, Inc. is a science-minded yet goal-oriented organization that is focused on bringing novel, first-in class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to enable the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Celgene for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group, and recently entered into a multi-year strategic collaboration with Celgene. The company is based in San Francisco, California.
About the Position
We are seeking a talented and highly motivated Scientist with a strong background in synthetic organic chemistry and DNA encoded chemistry to lead our library group in the pursuit of novel small molecules to treat patients with unmet medical needs. Specifically, this individual will lead a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate our key targets. The successful candidate will have demonstrated experience in evaluating and prioritizing chemical features from affinity selection experiments. A key responsibility will be to integrate with the existing medicinal chemistry team to rapidly scan outputs for drug-like hits that can be further optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.
• Ph.D. in synthetic organic chemistry with 8+ years industrial chemistry experience.
• High level of creativity and productivity with strong synthetic problem solving skills.
• Excellent scientific expertise in organic synthesis and specifically aqueous chemistry, conversant with the current literature.
• Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
• Ability and interest to innovate in both library chemistry and design.
• Solid appreciation of the sample management and logistics required for successful combinatorial library synthesis.
• Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
• Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
• Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
• Experience in utilization of linker technology and chemical biology probes a plus
Fit with Nurix Culture and Values
• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view
Application Process: Nurix requests that applicants write a cover letter communicating the reasons for their interest in the position as well as the reasons they believe they are a good fit. T