Senior Scientist - DMPK

Takeda California

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Location: San Diego, CA Posted Date: 4/29/2013 Position Type: Full time Job Code: 265 Required Education: Doctorate/PhD Areas of Expertise Desired: Biochemistry
Chemistry
Pharmacokinetics
Pharmacology

Description

Serve as DMPK expert to large and small molecule project teams, provide input into research strategies, and collaborate with global Takeda sites in advancing compounds to IND filing.


*   Support drug discovery and early development programs by providing relevant scientific and strategic input with respect to drug metabolism, pharmacokinetics, bioanalysis and PK-PD.
*   Design and implement in vitro and in vivo PK/ADME screening cascades for new compounds across several therapeutic areas.
*   Design, execute, and report key PK studies to support compound progression from lead optimization to clinical candidate selection
*   Collaborate with chemists to address structure-DMPK relationship and improve DMPK properties during lead optimization
*   Present and interpret relevant DMPK data to teams and the Takeda organization
*   Be responsible for the developability strategy on project teams
*   Predict PK, efficacious dose, and optimal dosing schedule in humans
*   Contribute equally with other project team members on high level project strategy
*   Advise project teams on design of pharmacology and safety studies, using modeling and simulation as needed
*   Work closely with department colleagues to coordinate work for project teams
*   Keep an accurate notebook according to company policy  
*   Communicate with colleagues effectively
*   Follow company safety procedures  

Requirements

*   BS/MS in Pharmaceutical Sciences/Chemistry/Biochemistry or related coursework and 8-10 years of relevant experience or a PhD with 2-5 years experience.
*   Thorough understanding of pharmacokinetics, pharmacodynamic, exposure-effect relationships. Large molecule PK experience is desired
*   DMPK leadership experience on project teams in early discovery is critical. Managing the ADME and PK screening paradigm in early lead optimization, as well as early phase 1 design and human PK predictions are minimum requirements.
*   Software proficiency in Phoenix and/or Watson, GastroPlus is desired
*   Bioanalytical experience is a plus
*   Experience in compiling and writing IND modules is a plus
*   Demonstrated ability to solve scientific problems creatively, effectively and independently
*   Demonstrated ability to work within a matrix and team environment
*   Excellent oral and written communication skills

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