The Senior Scientist of Chemical Development will investigate and support late stage process development primarily through laboratory work. Primary duties will focus on mapping process design spaces, identifying, tracking and synthesizing process impurities, and optimizing critical portions of chemical processes. The Scientist will also work on the design and implementation robust synthetic processes for early pre-IND and phase I development programs.
GBT places a high value on cooperative team dynamics and a positive, “can-do” work ethic. The ideal candidate thrives in a fast-paced environment where a strong sense of urgency is the norm and exceptional communication and interpersonal skills are needed.
• Laboratory experiments focused on synthetic process development on a small and kilo-laboratory scale.
• Maintain an accurate and comprehensive laboratory notebook that will be the basis of department presentations and technical reports.
• Use of HPLC, preparative HPLC, LC/MS, and 1H NMR to isolate and identify impurities.
• Effective coordination and interaction with analytical development and formulation development functions to ensure chemical development activities are in-line with other functions.
• Participate in an interactive, team oriented culture, interfacing primarily with the technical operations group but also with discovery and quality assurance functions.
• Opportunity to manage sub-projects within the scope of larger, key chemical development projects.
• Approximately 5-10% travel will be needed for monitoring of critical project and manufacturing activities at contract manufacturing organizations (CMOs)
• Doctoral degree with a minimum 5 years’ of experience, or a Master’s degree with a minimum of 8 years’ experience in small molecule synthetic organic chemistry. Chemical development laboratory training and hands-on experience in a kilo-laboratory setting required.
• Experience with late-stage pharmaceutical chemical development (Phase II to commercial) strongly desired.
• Understanding of the synthetic and analytical techniques necessary for proper polymorph screening and optimization.
• The ability to interact and effectively share synthetic route selection, design, and development knowledge with cross functional teams.
• An understanding of cGMPs, ISO, ICH guidelines, and industry best practices.
• Understanding of Design of Experiments (DoE) and Quality by Design (QbD) principals.
Drive, desire, motivation:
• Ability to thrive in a fast-paced, entrepreneurial environment with high performing colleagues
Fit with GBT culture:
• Ability to build strong relationships with co-workers of various backgrounds and expertise
• Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
• Values-based leadership consistent with GBT's Core Values
• Excitement about the vision and mission of GBT