AbbVie’s mission is to apply the expertise, dedication, and creativity of its people to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs more than 28,000 people worldwide and markets medicines in more than 170 countries.
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica®, Venclexta™, and Empliciti™ — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.
Stemcentrx is looking to hire a highly motivated scientist to elucidate the biology of DLL3 in high grade neuroendocrine cancers such as small cell lung cancer (SCLC). The successful candidate will also evaluate activity of rovalpituzumab tesirine (ROVA-T), an anti-DLL3 antibody drug conjugate (ADC), in various cancers and possible resistance mechanisms to the ADC. Responsibilities include: designing and executing experiments in vitro; designing in vivo studies in xenograft and syngeneic animal models; managing DLL3-focused internal and external basic research projects; interacting with scientists of varying experience across a multidisciplinary team; presenting data at internal and external meetings.
Education & Experience Required:
• Ph.D. with 0-3 years post-doctoral experience, or M.S. with 8+ years of experience, including management of research projects with fixed timelines
• Strong publication record in cancer biology, and preferably Notch pathway biology
• Expertise in mouse genetics (transgenes/knockout) and/or mouse models of tumorigenesis and knowledge of developmental pathways dysregulated in cancer
• Broad experience elucidating cancer and/or developmental signaling pathways (Notch, Wnt, etc) in mammalian model systems
• Technical expertise in molecular biology, mouse and/or human genetics, phosphoflow (flow cytometry), reverse phase protein arrays (RPPA), immunoprecipitations, western blots, knockdown and overexpression studies, immunofluorescence
• Excellent laboratory, record keeping, data analysis, and critical thinking skills
• Self-motivated and able to consult the primary scientific literature, design experiments to test hypotheses and present data to the team
• Strong communication skills (verbal, written, interpersonal) and the experience managing internal and external research projects
• Good time management (schedules, timelines, task prioritization) and the ability to adapt to changing priorities in a fast-paced environment