Senior Research Specialist, Protein Chemistry - South San Francisco, CA | Biospace
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Senior Research Specialist, Protein Chemistry

Five Prime Therapeutics, Inc.

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to alter the tumor microenvironment to enhance tumor cell killing. Our company has a growing portfolio of product candidates and currently has three protein therapeutics in clinical development.   

  •      Cabiralizumab (FPA008) – a monoclonal antibody targeting CSF1R in a Phase 1/2 clinical trial in pigmented villonodular synovitis (PVNS) and in a Phase 1a/1b clinical trial in multiple cancers in combination with Bristol-Myers Squibb Company’s PD-1 immune checkpoint inhibitor, Opdivo® (nivolumab)    
  •      FPA144 – a monoclonal antibody targeting FGFR2b in a Phase 1 clinical trial in FGFR2b over-expressing gastric cancer    
  •      FP-1039 – an FGF ligand trap in a Phase 1b clinical trial in mesothelioma    

   Five Prime has a differentiated target discovery platform and library that we use to rapidly interrogate the entire extracellular proteome in medically relevant in vitro and in vivo models to discover novel targets and drug leads.  Our technology has been validated by our growing pipeline and through multiple collaborations with pharmaceutical companies, including Bristol-Myers Squibb, UCB Pharma, S.A. and GlaxoSmithKline across a range of therapeutic areas.  FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at  


   We are seeking a talented and highly motivated Senior Research Specialist to join our Protein Chemistry group as part of the Biotherapeutics department to support Research discovery and pre-clinical therapeutic programs in a dynamic, team-oriented and collaborative environment.  This position reports to the Executive Director, Protein Chemistry.  

   Essential Functions:  

  •      Perform small-scale protein expression, purification, and biophysical and functional characterizations for target proteins, antibodies, and other protein formats    
  •      Design, validate and implement robotic protein production systems.    
  •      Work closely with Antibody Engineering Technologies and Discovery Research to support lead candidate development    
  •      Other projects as needed    



  •      Bachelor’s degree with 10 years of laboratory experience or Master’s degree with 8 years of laboratory experience in biochemistry, cell biology, or molecular biology.    
  •      Minimum of 5+ years of experience in protein purification or related biochemistry areas    
  •      Experience with recombinant protein expression at multiple scales using mammalian culture processes required, with microbial experience a plus    
  •      Prior experience with protein engineering technologies producing monovalent and bispecific antibody formats is a plus    
  •      Experience with protein biochemical and biophysical characterization techniques including Biacore, Octet, IEX-HPLC, SEC and CE    
  •      Familiarity with high throughput technologies for production, characterization, and functional testing of new therapeutic proteins is a plus    
  •      Strong written and interpersonal communication skills are required.    
  •      Ability to work both independently and as part of a team in a collaborative environment    
  •      Organized and well-planning to meet deadlines Detail-oriented and positive “can-do” attitude towards assigned responsibilities