Senior Research Associate, Oncology Research Unit (Non-PhD) - New York, NY | Biospace
Get Our FREE Industry eNewsletter

Senior Research Associate, Oncology Research Unit (Non-PhD)

Pfizer Inc.

New York, NY
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

About Pfizer

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

Research Scientist to provide assay and shRNA/CRISPR reagent generation support for Oncology Target Discovery (OTD) group projects. This will include providing: 1) Cell culture and molecular biology cloning support for shRNA/CRISPR gene target construction and validation 2) Developing and running screens using libraries of small molecule inhibitors, shRNA or CRISPR gene targets reagents 3) Performing weekly analysis and providing data results for screens and assays


* Provide cell culture and molecular biology support for shRNA and/or CRISPR reagent generation
* Perform lentiviral cell transduction support for both immune and tumor cells for screens
* Use Biomek and Janus liquid handling platforms for developing high throughput assays and screens
* Provide weekly updates and analysis of screen and assay data
* Manage assay reagents, compound ordering, and inventory tracking
* Support development of new technologies and innovative approaches that aid in increased throughput or improvement in reagent quality, assay performance, or sensitivity



Education and Experience: * Master's degree preferred with 5+ years' experience, or Bachelor's degree with 6+ years' experience, preferably in the pharmaceutical industry
* Prior work experience in industry is not required, but would be beneficial. Attributes: * Highly motivated and independent scientist who drives results to deliver on specific goals
* Strong analytical thinker who strives to improve, innovate, and become a scientific leader Technical Skill Requirements: * Strong demonstrated experience and knowledge in molecular biology techniques including but not limited to cloning, PCR, plasmid purification and quantification
* Experience in cell culture, lentviral packaging, tittering and infection for shRNA or CRISPR vectors
* Experience running either small molecule, shRNA, or CRISPR arrayed assays or screens
* Experience using High Content imaging (Arrayscan or Opera) or FACS platforms desired
* Expertise using semi-automated Biomek, Janus, Tecan or similar liquid handling platforms desired
* Experience in performing MiSeq or other NGS analysis would be beneficial but not required
* Experience in performing shRNA or CRISPR pooled screens would be beneficial but not required PHYSICAL/MENTAL REQUIREMENTS Basic physical requirement needed; no heavy lifting involved. Strong mathematical skills required with demonstrated experience working with databases such as LIMS, Freezer Pro, or other similar platforms.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.