Senior or Principal Scientist, Assay Development – Next Generation Sequencing - Tucson, AZ | Biospace
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Senior or Principal Scientist, Assay Development – Next Generation Sequencing

HTG Molecular Diagnostics

Tucson, AZ
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Assay Development, Principal Scientist, Senior Scientist,

Job Description

Headquartered in Tucson, Arizona, HTG’s mission is to empower precision medicine at the local level. In 2013, the company commercialized its HTG Edge instrument platform and a portfolio of RNA assays that leverage HTG’s proprietary nuclease protection chemistry. HTG’s product offerings have since expanded to include its HTG EdgeSeq product line, which automates sample and targeted library preparation for next-generation sequencing. Additional information is available at

HTG is committed to bringing the highest level of simplicity and automation to molecular diagnostics by leveraging proprietary nuclease protection assays and coupling it to next generation sequencing. Our pipeline includes gene expression and mutation based assays in low multiplex using a microarray format and in high multiplex as a front end to Next Gen Sequencing.

HTG is looking to add to its professional team a dedicated scientist with the expertise to develop new compelling products to meet the increasing need for next generation sequencing at clinical laboratories of the future.  This is a laboratory-based position for a scientist with hands-on molecular and computational experience with DNASeq and RNAseq methods to develop assays for the detection of clinically important gene fusions and mutations. The key elements for success are deep technical and assay development expertise, a passion for solving vexing clinical laboratory workflow issues, and ability to communicate effectively with molecular and computational scientists.

•   Development and validation of clinical NGS assays on the EDGE platform
•   Write and review all technical documents associated with assay development including SOPs, validation material, presentations, and publications
•   Maintain a high level of quality in the diagnostic development processes
•   Implement and ensure strict adherence to quality control and quality assurance measures of clinical NGS assays
•   Ensure adherence to all regulatory guidelines
•   Provide scientific and technical input in internal and clinical trial projects
•   Work with a cross-functional team to complete specific projects


PhD in genetics or molecular biology or a related field. 3+ years of experience in a translational research or a clinical laboratory setting. Expertise in pertinent areas such as sequence analysis, online human genomics resources, and molecular test design, as well as fundamental knowledge in oncology or Human Genetics is a Plus.

Nestled at the foothills of the majestic Catalina Mountains, and ringed by 4 other mountain ranges, a young and family friendly modern metropolis, Tucson offers 360 days of sunshine, unparalleled golf, museums, historic sites and hiking trails where one can experience the wide variety of animal and plant life of the Sonoran Desert, one of the most biodiverse spots on the planet.

HTG offers competitive salaries and an attractive benefits package including 100% employer payed medical and dental benefits, long term disability insurance, employee stock purchase plan, as well as stock options upon hire, relocation assistance and the unique ability to work with cutting edge technological advances.