Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.Summary:
The Head of Biology in the Protein Homeostasis Thematic Center of Excellence is primarily responsible for leading the biology teams to support the Discovery effort in developing novel therapies in this area. This represents a key area of research for Celgene, building on the success of the IMiD like drugs targeting the cereblon E3 ligase. However, the scope of this program extends beyond this target to other E3 ligases and other UPS targets including the deubiquitinases. In addition, this will include research on novel approaches to hijacking E3 ligases to facilitate targeted protein destruction by the proteasome. These programs will support both Oncology and Inflammation & Immunology (I&I) discovery projects.
The successful candidate will lead a group of PhD and non-PhD level scientists supporting Lead Programs in Discovery, developing candidate drugs targeting areas of unmet need in hematological and oncological diseases and serious inflammatory conditions. Candidates will have extensive experience in the biology of these indications and in the discovery and pre-clinical development of therapeutics for lymphoma, leukemia, solid tumors and non oncology indications. The role will include responsibility for defining the strategy of the Biology Team and for its implementation. This role will be responsible for determining resources required to support the PH TCoE programs in co-operation with the PH TCoE Lead. This role plays a key part in determining the PH TCoE strategy on target selection and supporting key projects through to clinical proof of concept. He/She will be a key member of the PH Leadership Team and will be responsible for the recruitment, supervision and support of laboratory research staff behind the drug discovery project teams. In addition he/she will be responsible for experimental design, and regular review of project strategy and execution towards the nomination of Development Candidates.
Will provide training to new staff and less experienced employees, as necessary. Will act as scientific leader in areas of expertise, and will advocate for department goals at governance committees and other interdisciplinary venues. Will make scientific presentations both internally and externally when appropriate. Employee will assist in the writing of non-clinical pharmacology study reports, will submit invention disclosures to support the patent process, and will write and publish peer-reviewed articles when appropriate and concordant with company interests. Employee will exhibit leadership strengths, and depth of scientific understanding in hematology and oncology. Responsible for the management of external research work via contract research laboratories, and academic collaborations.
Key leadership role within the TCoE to deliver strategic input and to identify and evaluate new external opportunities. The incumbent will have excellent communication skills and be required to interface with other Thematic Centers and Support Departments across the Research and Development Organization.
Responsibilities will include, but are not limited to, the following:
The Senior Director is responsible for leading the overall scientific, technical and operational efforts of the Protein Homeostasis TCoE in support of Discovery Project Teams. This includes developing appropriate assays against targets defined by the therapeutic areas and being responsible for the quality and interpretation of the data produced. Responsible for development of strategy for testing lead compounds in relevant disease models in vitro and in vivo, to understand mechanism of action and to optimize therapeutic usage strategies.
Sets the standard for quality research within the Biology Team and contributes to regular review of the project strategy and execution towards the nomination of Development Candidates.
Assumes responsibility for writing non-clinical pharmacology study reports, invention disclosures, as well as portions of clinical study protocols, investigator brochures, and regulatory documents such as INDs and NDAs.
Is responsible for identifying potential collaborations in academia and/or industry in support of the Project Teams. Contributes to Business Development reviews and will regularly provide expert opinion during due diligence activities.
Facilitates communication of results and potential issues and plans with key stakeholders. Allocates resources and ensures tracking and follow-up as necessary.
Responsible for setting high standards, building and managing a high performing biology team within the PH TCoE. Sets performance objectives, supports personnel development and addresses performance issues. Responsible for recruiting/hiring/promoting personnel as appropriate. Develops internal talent through coaching, training and other relevant experiences that meet the needs of the organization. Allocates proper resources for meeting goals and objectives.
Maintains effective communications with staff, and interacting Departments and the broader R&ED group. Regularly exchanges ideas and information to develop effective plans and strategies to meet business needs. Provides routine updates and explains decisions to review committees. Understands needs and considers external customers and/or internal clients in decisions and actions. Encourages and supports collaboration across departments and takes actions that are best for Celgene.
- Sets high performance expectations and holds others accountable for the results expected.
- Encourages new ideas and processes, and encourages new approaches.
- Promotes a culture of scientific and technical excellence, multidisciplinary problem solving, teamwork, consistency, flexibility, execution, quality and effective communication.
- Influences and impacts others through building and maintaining strong networks that are leveraged to obtain critical information and accomplish objectives.
- Anticipates needs, assesses and manages business risks and organizational dynamics
- Recognizes and resolves broad based complex issues across organizational boundaries.
- Develops and delegates appropriately
- Identifies key skills gaps in the organization
Scope:Establishes operational goals and objectives for a department or sub function. Directs the operations and activities of a department, service, product or function at a significant or geographic business unit or corporate level. Develops functional policies that impact the overall direction or success of the company. Rarely becomes involved in daily/transactional operations; work is more focused on ensuring budgets, goals and performance standards are set and attained.
Supervision (given and received):
Accomplishes results through lower-level management on teams. Establishes organizational structures within own team. Focus is on meeting short-range goals and influencing the long-term direction of the department or function. Work is reviewed for progress vs. long-term objectives. Seeks senior management guidance on matters of extreme complexity or sensitivity. Seeks management approval on only decisions that would affect long-term functional success.
Interaction / Liaison:
Interacts regularly with senior management and members of executive team. Has frequent interaction with external contacts and usually at senior levels within industry or with vendors.
Sets objectives for and manages multiple projects/on-going work activities of high complexity. Manages a departmental or project budget and has authority to allocate company resources according to need.
Ph.D. with at least 16 years of relevant work experience required. Ideally, someone with at least 5 years experience at the Director level.
An advance graduate degree in a field of biomedical science related to hematology or oncology (Ph.D.) with at least 16 years of laboratory research and/or management experience in Industry or in Academia.
Research experience in the field of protein homeostasis and/or drug discovery is preferred
Industry experience valuable but not essential
Excellent communication skills to effectively convey scientific concepts and data at the corporate level, with internal working groups/project teams and external academic and industrial organizations.
Team player, mentoring ability, excellent supervisory skills.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.