Scientist/Senior Scientist - Intracellular - South San Francisco, CA | Biospace
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Scientist/Senior Scientist - Intracellular

NGM Biopharmaceuticals, Inc.

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Location:
South San Francisco, CA
Posted Date:
12/2/2016
Position Type:
Full time
Job Code:
98-181
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Biochemistry, Scientist, Senior Scientist,

Job Description

NGM Biopharmaceuticals, Inc. is a private, maturing biotech start-up dedicated to discovering the next generation medicines to treat grave diseases. Our experienced scientific team has joined forces with an impressive group of industry professionals, Nobel Laureates, and other distinguished researchers to form a company where innovation and cutting edge science will provide the foundation for a robust drug discovery engine. In 2015, we established a broad collaboration with Merck that will provide us with the resources and flexibility to pursue our ambitious research and development goals. This partnership is a strong validation for NGM as a biologics discovery engine that will generate transformational medicines for unmet medical needs.

Live cells have intact cell membrane structures which are not permeable to large molecules and proteins. Targeting an intracellular pathway by a proteinaceous molecule has traditionally been accomplished by receptor mediated endocytosis followed by translocation of the protein into the target subcellular locals through active translocation mechanisms. In NGM, we are interested in bringing proteinaceous molecules to specific subcellular locations so that we can access intracellular targets with biologics. The approaches will be mainly based on, but not limited to, bacterial toxin fusion to bring engineered fusion proteins to disrupt intracellular activities. To strengthen our effort in this project, we are offering an exciting research opportunity for a scientist to join our research team. We offer an exciting working environment, the possibility to work with experienced scientists and competitive salary and benefits.

The candidate will focus his/her research on:
1.   Using bacterial toxin, membrane penetrating peptides and other means to bring warhead proteins into live cells.
2.   Generate a proof-of- concept molecule that consists of a targeting moiety for binding to a specific cell surface target; a membrane translocation moiety for bringing a warhead into cells; and a warhead moiety for targeting a specific biological process.
3.   Demonstrate an efficacy of this molecule in both cell based assay and in an animal model.
4.   In addition, the candidate will utilize innovative protein engineering technologies to generate a drug-like protein therapeutics with in vivo efficacies in a disease model.

Requirements

•   Ph.D. in Biochemistry, Molecular Biology and Cell Biology or related fields with a proven track record of innovation.
•   Extensive experience in protein/antibody engineering and experience including protein expression, purification/characterizations and functional assays.  Experience in in vivo animal model is desirable but not required.
•   Self-motivated with ability to work independently.
•   High productivity in research as demonstrated by previous strong publication record.
•   Demonstrated ability in tackling difficult projects through dedication and perseverance.
•   Excellent written and verbal communication skills and ability to supervise research associates.

NGM offers a creative, collaborative, highly challenging scientific environment, along with a strong compensation package that includes salary, stock options, 401(k) and a comprehensive benefits package.