Scientist/Research Scientist, Medicinal Chemistry - San Francisco, CA | Biospace
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Scientist/Research Scientist, Medicinal Chemistry

FibroGen, Inc.

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Location:
San Francisco, CA
Posted Date:
5/17/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Medicinal Chemist, Research Scientist, Scientist,

Job Description


We are seeking a highly motivated and enthusiastic Medicinal Chemist to join the Chemistry group at FibroGen.

Responsibilities:

The successful candidate will plan and execute the synthesis, purification, and characterization of small molecule compounds for evaluation in drug discovery projects. As a Medicinal Chemist at FibroGen you will work independently as well as of part of a team. You will contribute to drug design, develop new synthetic routes, perform SAR analyses, and stay up-to-date with the relevant scientific literature. In addition, you will maintain clear and accurate records of your experimental work and provide regular written and oral progress reports.

FibroGen, Inc., headquartered in San Francisco with subsidiary offices in Beijing and Shanghai, is a leading science-based biopharmaceutical company discovering and developing a pipeline of first-in-class therapeutics. The company applies its pioneering expertise in fibrosis and hypoxia-inducible factor (HIF) biology and clinical development to advance innovative medicines for the treatment of anemia, fibrotic disease, and cancer. Roxadustat (FG-4592), the company’s most advanced product candidate, is an oral small molecule inhibitor of HIF prolyl hydroxylase activity in Phase 3 clinical development for the treatment of anemia in CKD. Pamrevlumab (FG-3019), a fully-human monoclonal antibody that inhibits the activity of connective tissue growth factor (CTGF), is in Phase 2 clinical development for the treatment of idiopathic pulmonary fibrosis (IPF), pancreatic cancer, and Duchenne’s muscular dystrophy (DMD). FibroGen is also developing a biosynthetic cornea in China. For more information, please visit www.fibrogen.com.

Requirements


•   Ph.D. in synthetic organic chemistry and 0 – 4 years of relevant post-graduate work: prior exposure to the pharmaceutical or biotech industry is a plus but not mandatory
•   Extensive practical experience in designing and performing organic syntheses
•   Detailed and up-to-date knowledge of synthetic organic chemistry
•   Ability and interest to acquire/maintain a sound knowledge of medicinal chemistry and relevant biology topics
•   Outstanding creativity, analytical and problem-solving skills
•   Excellent written and oral communication skills
•   Knowledge and compliance of safe laboratory practices