Scientist Proteomics and Biomarkers

If you are looking for an uncommon opportunity -- a chance to join an organization known for its scientific excellence in the research and development of pharmaceuticals -- it's time to consider Regeneron.

Regeneron is a fully integrated biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions.  Regeneron markets three products in the United States, EYLEA® (aflibercept) Injection, ZALTRAP® (ziv-aflibercept) Injection for Intravenous Infusion, and ARCALYST® (rilonacept) Injection for Subcutaneous Use; ZALTRAP is co-commercialized with Sanofi.  Phase 3 studies are in progress with EYLEA in two additional indications and with product candidates sarilumab and REGN727.  Regeneron has active research and development programs in many disease areas, including ophthalmology, inflammation, cancer, and hypercholesterolemia.

Summary:
Summary: We are looking for a highly motivated Scientist to join the Proteomics and Biomarkers group within the Therapeutic Proteins team.  A Ph.D. level scientist is needed to carry out labeled (SILAC) and non-labeled quantitative proteomic analysis of preclinical samples for biomarker discovery. The candidate must have extensive hands on experience running and maintaining Orbitrap instruments.

Responsibilities include, but are not limited to:
- Develop and optimize subcellular fractionation methods for in-depth proteomics
- Carry out label-free quantitative proteomic analysis of preclinical samples for biomarker discovery
- Supervise research associates in performing routine proteomic workflow such as multiple enzymatic digestion, OFFGel separation of peptides, GELFREE fractionation of proteins, LC-MALDI, and NanoLC-MS/MS
- Maintain the operation of Orbitrap Elite mass spectrometer coupled with EASY-nLC II

This position requires a PhD in Chemistry, Biochemistry or related field, and 3-5 years postdoc training in a Proteomics centered lab.  Additional requirements include:

- Deep knowledge of peptide/protein chemistry and mass spectrometry
- Extensive hands-on experience and trouble-shooting skills in nanoLC-L TQ-Orbitrap MS
- Proven experience in multiple-stage fractionation and subcellular enrichment
- Competence in label-free quantitation software e.g. SIEVE and Mascot Distiller preferred
- Highly motivated and able to work productively in a fast-paced team environment
- Excellent communication skills required
- Prior managerial experience is a plus.

We offer a competitive compensation and benefits package including stock incentives, 401k with company match as well as the expected health and welfare benefits. Comprehensive relocation benefits are available, as required.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply to us today and find out what we mean when we say that, at Regeneron, we have an unwavering commitment to combining good science & good business.

EOE/M/F/D/V  

Disclaimer:  Regeneron is not accepting unsolicited assistance from search firms/employment agencies for this employment opportunity.  Please, no phone calls or emails to any employee of Regeneron about this opening.  All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the Internet or in any form and/or method without a valid written search firm agreement in place for this position will be deemed the sole property of Regeneron.  No fee will be paid in the event the candidate is hired by Regeneron as a result of the referral or through other means.  Moving forward, Regeneron is using the agency management company, Candex -

ARCALYST, EYLEA, and ZALTRAP are trademarks of Regeneron Pharmaceuticals, Inc.