Scientist - Protein Expression and Cell Line Development - Brisbane, CA | Biospace
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Scientist - Protein Expression and Cell Line Development

Maverick Therapeutics

Location:
Brisbane, CA
Posted Date:
7/9/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Masters Degree
Areas of Expertise Desired:
Antibody, Assay, Assay Development, Biochemistry, Biologist, Biology, Biology Research, Biomarker, Biotechnology, Cancer, Cell, Cell Biology, Cell Culture, Development, Drug Discovery, Elisa, Flow Cytometry, Genentech, HPLC, Immunohistochemistry, Immunology, Laboratory, Mass Spectrometry, Molecular Biology, Oncology, PhD Biology, PhD Molecular, Research, Research Scientist, Scientist, Scientist Biology, Scientist Immunology, Scientist Molecular Biology, Scientist Oncology,

Job Description

Maverick Therapeutics is a small start-up company developing new platforms of T-cell engaging protein therapeutics for cancer treatment.

We are seeking a SRA/Scientist with expertise in high-titer stable cell line generation, transient expression, purification, and characterization of antibodies and other proteins produced in mammalian expression systems to contribute to our drug discovery efforts.

Responsibilities:

*  Generation and selection of stable CHO pools and clones for production of therapeutic proteins on industrial scale

*  Perform upstream protein expression via transient transfections using various mammalian expression, including CHO and HEK293 systems, to support small and large scale production of therapeutic proteins for research, in vivo studies, and PK studies.

*  Assist with downstream protein processing including purification steps, concentration, formulation, aliquoting, and biochemical QC characterizations.

*  Maintain database inventory and schedule for protein production supply/demand.

Requirements

*  BS or higher in Biochemistry, Chemistry, Biology or a related field with 5+ years of relevant experience with protein expression, purification and characterization.

*  Experience with mammalian expression systems, antibody production, cell line development is required.

*  Experience with production of bispecific antibodies is a plus.

*  Excellent presentation skills (written and oral) and the ability to coordinate with and collaborate on a multidisciplinary team while meeting timelines.

*  Ability to work independently with a strong work ethic.