Scientist - Pharmacokinetics and Drug Metabolism - Cambridge, MA | Biospace
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Scientist - Pharmacokinetics and Drug Metabolism


Cambridge, MA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

Amgen is seeking a Scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.

In this role you will add to the discovery and non-clinical development of small and large molecule therapeutics. You will be responsible for establishing and implementing PKDM strategy to achieve project team goals integrating pharmacokinetic and pharmacodynamic (PKPD) analysis with other aspects of drug discovery including disease biology, chemistry/protein sciences, toxicology and clinical pharmacology to advance the best therapeutic candidates.  In addition, this position will make meaningful and innovative contributions to PKPD modelling and simulation in support of Amgen's drug discovery efforts.

In this position the core responsibilities are to:

Serve as a subject matter expert on the pharmacokinetics and pharmacodynamics of small and large molecule therapeutics, communicate results, and collaborate with scientists cross-functionally and across our three-site PKDM scientific community (Cambridge, MA, San Francisco and Thousand Oaks, CA)

Work with the PKDM project team representative and/or directly with disease and biology experts to design appropriate pharmacodynamic (PD) studies to evaluate biology, PD and/or efficacy models, and to establish PKPD relationships to best meet therapeutic objectives

Devise, articulate, and implement strategies for improvement of the PKPD properties for candidate molecules and influence candidate selection

Communicate with PKDM project team representatives, experimentalists and modelling experts from clinical pharmacology to bridge the gaps from the laboratory bench to mathematical models and from discovery to development  

In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the pharmacokinetic and pharmacodynamics properties of small and large molecule therapeutics.  A collaborative and highly capable scientific cross-site community at Amgen is available to support these efforts.  Interactions and collaboration with academic and other external scientists is encouraged.



Basic Qualifications

Doctorate degree


Master's degree and 4 years of scientific experience


Bachelor's degree and 6 years of scientific experience

Preferred Qualifications

Ph.D. in pharmaceutical, chemical, or biological science or BA/MS with equivalent experience

2+ years of drug discovery and/or development experience

Knowledge/expertise of PK, PD and/or distribution of small molecule and biological therapeutics

Expertise using PKPD modelling platforms (e.g. WinNonlin, Phoenix, Matlab)

Critical thinking, and demonstrated ability to communicate with team members across broad disciplines

Effective oral and written communication skills.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.