Scientist - Oncology Target Discovery - Waltham, MA | Biospace
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Scientist - Oncology Target Discovery

AstraZeneca Pharmaceuticals LP

Waltham, MA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

                                       Location:Waltham, United States
Job reference: R-001721
Posted date: Dec. 01, 2016


At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a Scientist, Oncology Target Discovery, in Waltham, MA you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas.

AstraZeneca's vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. As well as other tumor types, these are being targeted through four key platforms - immunotherapy, the genetic drivers of cancer and resistance, DNA damage repair, and antibody drug conjugates, underpinned by personalized healthcare and biomarker technologies

Main Duties and Responsibilities

As a Scientist in Oncology Bioscience at AstraZeneca, you'll be a key member of a dynamic and collaborative team, responsible for applying genetic, molecular and cellular approaches to progress drug discovery efforts. This is an excellent opportunity to apply your knowledge of cancer biology and target validation to contribute to the oncology portfolio. This work will generate compelling preclinical data packages which drive promising drug discovery projects towards clinical development

You'll be responsible for generating and testing hypotheses to drive understanding of novel drug projects, defining and delivering high quality bioscience studies, analyzing and interpreting data, and communicating the key findings in a timely manner to multi-disciplinary teams


Essential Requirements:

  • A Bachelor, Master or PhD with relevant experience, preferably in an industry setting

  • Hands-on experience in CRISPR/Cas9 technology including optimization of experimental conditions, cutting efficiency and assay development using mechanistic and viability endpoints

  • Experience in cancer genetics and cancer biology

  • Excellent problem-solving skills

  • Ability to work in a team-oriented environment


Desirable Requirements:

  • Drug discovery experience, gained at a biotech or pharmaceutical company

  • Experience in liquid handling technologies for biological assays

  • Prior experience in assay development for irreversible inhibitors such as target occupancy assays

  • Prior experience in projects related to cell death and DNA damage response pathways


Next Steps -- Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience -- it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.