Scientist - Molecular Profiling I/O - Tarrytown, NY | Biospace
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Scientist - Molecular Profiling I/O

Regeneron Pharmaceuticals, Inc.

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Location:
Tarrytown, NY
Posted Date:
12/2/2016
Position Type:
Full time
Job Code:
6284BR
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including oncology, rheumatoid arthritis, asthma, atopic dermatitis, pain, and infectious diseases.

Summary:
The Molecular Profiling group is looking for a Scientist to analyze immuno-oncology (I/O) clinical, preclinical, and public profiling data to support I/O target mechanism studies, biomarker and target discovery & development, as well as implement and develop I/O data analysis pipeline using cutting-edge algorithms and statistically sound methodologies.

Responsibilities:

  • Collaborate with I/O scientists in preclinical and clinical departments to design profiling experiments and draft data analysis plan
  • Communicate results with I/O scientists, refine analysis based on feedback, and plan/prioritize follow-up experiments
  • Prepare clear, concise and easy-to-understand presentations and documentations for collaborators, senior management and government agencies
  • Analyze proprietary and public profiling data to support I/O targets and biomarker discovery
  • Analyze proprietary tox profiling data to support Tox studies
  • Analyze proprietary clinical profiling data to support Clinical studies
  • Contribute to team effort of developing I/O data analysis strategies and establishing I/O data analysis best practices
  • Participate in team effort of organizing and integrating proprietary and public molecular profiling data to enable data sharing and visualization for bench scientists

    Requirements

    This position requires a minimum of a PhD in a related field, and preferably 2+ years postdoctoral experience. Additional requirements include, but are not limited to:
  • Expertise in immuno-oncology
  • Expertise in NGS data analysis to detect gene expression, variants, copy number variation, fusion and alternative splicing
  • Strong preference for R power users, especially DeSeq 6+
  • Strong preference for experience in Single Cell Sequencing
  • Experience with analyzing cancer profiling data in the public domain such as TCGA
  • Experience with a variety of molecular profiling platforms such as microarray and NGS, and their data analysis best practices
  • Familiarity with TCR repertoire sequence analysis, antigen prediction, modeling (e.g., machine learning) and network building (e.g. gene regulation networks): Keen interest and determination to be at the cutting-edge of algorithms and model building
  • Familiarity with bioinformatics tools and software such as R/Matlab, Linux, Perl, Python, Ruby, Java, Ruby on Rails, SQL, web programming
  • Ability to work both independently and collaboratively
  • Team spirit and commitment to share and collaborate
  • Excellent communication and presentation skills

    Preferred skills:
  • Experience with Structural and Computational Biology and Bioluminate is a plus

    This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

    To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

    Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.