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Scientist, Medicinal Chemistry

Otsuka America Pharmaceutical, Inc.

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Location: Rockville, MD Posted Date: 4/18/2013 Position Type: Full time Job Code: 2807 Required Education: Doctorate/PhD

Description

The Scientist, Medicinal Chemistry, will:

• initiate, direct, and execute all OMML pre-clinical scientific research and/or development strategies in an oncology field
• investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems
• plan and execute laboratory research
• maintain knowledge of state-of-the-art principles and theories
• make major contributions to scientific literature and conferences
• interface with various departments and serve as internal consultant
• act as spokesperson on corporate research and development and advise top management
• participate in development of patent applications

When involved in an anti-cancer drug discovery project, the Scientist, Medicinal Chemistry,

• contribute to the development and enablement of a coherent synthesis strategy for oncology drug discovery project(s)
• understand the goal and strategy of the project and, as part of a synthesis team, positively and proactively influence and reduce to practice through the development of innovative and practical chemistry
• design, synthesis, purification and characterization of biologically-active organic small molecules as development candidate for the drug discovery programs
• develop and enable versatile and modular synthetic routes compatible with rapid analog synthesis. Validation of routes through reduction to practice
• develop scalable routes of preclinical drug candidates
• maintain a detailed scientific notebook, analytical data and other scientific information
• prepare reports and write up experimental to support patent filing
• present data and progress internally and externally when necessary
• maintain a clean and safe laboratory environment; perform routine maintenance on laboratory instruments such as HPLC and vacuum pumps
• publish and present research internally and externally to Otsuka
• take personal responsibility for individual and co-worker safety and strictly adhere to all safety procedures and policies
• build effective partnerships with other lines, in particular analytical, technology, pharmaceutical sciences and process chemistry groups in Otsuka Japan.

Requirements

• Ph.D. in a scientific discipline, and a minimum of 5+ years of demonstrated experience in the pharmaceutical industry
• expertise in synthetic organic chemistry methodologies, transformations and mechanisms
• strong knowledge of techniques related to purification and characterization of organic compounds
• excellent written and oral communication skills; enthusiasm, self-motivation, strong interpersonal skill, able to interact effectively within a multidisciplinary team

Preferred

• 1-2 years of relevant post-doctoral experience is preferred
• practical experience of Structure or Ligand Based Drug Design and in silico screening with operating modeling soft.
• previous experience in mentoring and development of junior scientists or students is a plus.
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