Celgeneis a global biopharmaceutical company leading the way in medical innovation tohelp patients live longer, better lives. Our purpose as a company is todiscover and develop therapies that will change the course of humanhealth. We value our passion for patients, quest for innovation, spiritof independence and love of challenge. With a presence in more than 70countries - and growing we look for talented people to grow our business,advance our science and contribute to our unique culture.
Employee will have in-depth knowledge of hematological malignancies and oncogenic signaling pathways with excellent laboratory technical skills in areas of cell and molecular biology. Unique expertise in multiple myeloma, chronic lymphocytic leukemia or other B cell malignancies a plus. Being well versed in the scientific literature, employee will use current techniques to address questions of drug mechanism of action, differentiation and resistance using primarily in vitro methods. In vivo studies will be coordinated through a separate research facility, contract research laboratories, and academic collaborations. Will be responsible for well-defined and controlled experiments being mindful of translational relevance; Responsible for experimental design, interpretation of results and making scientific presentations to senior management. Employee will keep an electronic laboratory notebook and write non-clinical pharmacology study reports.
1.Develop in vitro assays for evaluating mechanisms of drug resistance, drug differentiation and pharmacodynamic marker identification (develop resistant cell lines, make stable knock-downs and knock-ins, cellular trafficking studies)
2.Study the intracellular signal transduction cascades and feedback mechanisms within pertinent cell types to assess mechanism of action and rationalize drug combination strategy.
3.Interface with bioinformaticians to analyze genomics data for understanding pathways of resistance and differentiation of Celgene drugs in development
4.Participate in translational team meetings to present data and provide interpretaion
5.Supervise Associate Scientist(s) and/or Research Associate(s) as needed, and under the direct but limited supervision of management.
6.Analyze, interpret, and report experimental results.
7.Establish and maintain working relationship with contract laboratories and relevant academicians
8.Responsible for the evaluation of subordinates and recommends promotions, merit increases and/or adjustments.
9.Ensures that the Translational Development Department maintains current awareness in area of expertise, enhances the scientific credibility of Celgene through contributions to the scientific literature (publications/presentations), through extramural activities and scientifically related interactions with academics
10.Assumes responsibility for writing non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate.
The position requires anindividual with:
An advance graduate degree in a field of cell biology,biochemistry or pharmacology (Ph.D. orequivalent) with at least 2 years of hands-on research experience. Industryexperience in drug discovery or translational medicine in the pharma or biotechsetting is a plus. Experience inhematological malignancies particularly lymphoma or CLL a plus.
Excellent communication skills to effectively convey scientificconcepts and data with internal working groups/project teams and externalacademic and industrial organizations.
Team player, excellent written and verbal communication skills
The incumbent must have planning skills for scheduling experimentalstudies to meet project team deadlines. The position requires problem solving abilityand skills in resolvingtechnical questions in a multi-disciplinary environment. The incumbent must keep abreast of currenttechniques within the field and the various scientific areas affecting hematologicalcancers. Must have keen interest in drug development.
Supervises internal researchassociates as required.
The position is responsible for planning and executing research plansin the defined area of investigation. This position has responsibility for thequality, quantity, timeliness, and scientific acceptability of drug discoveryactivities that result in reports that are required for internaldecision-making.
Celgene iscommitted to equal opportunity in the terms and conditions of employment forall employees and job applicants without regard to race, color, religion, sex,sexual orientation, age, gender identity or gender expression, national origin,disability or veteran status.
Celgene complieswith all applicable national, state and local laws governing nondiscriminationin employment as well as employment eligibility verification requirements ofthe Immigration and Nationality Act. All applicants must have authorization towork for Celgene in the U.S.