Scientist II / Senior Scientist I, Assay Development - South San Francisco, CA | Biospace
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Scientist II / Senior Scientist I, Assay Development

AbbVie Stemcentrx

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Location:
South San Francisco, CA
Posted Date:
8/17/2017
Position Type:
Full time
Job Code:
1705092
Salary:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

Oncology is
a key therapeutic area for AbbVie, with a portfolio consisting of three
marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline
containing multiple promising new molecules that are being studied in nearly 200
clinical trials in 19 different types of cancer.



AbbVie is expanding its oncology
hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood
City, South San Francisco, and Sunnyvale) focused on the discovery and
development of novel oncology therapies. More than 1,000 AbbVie scientists,
clinicians, and product developers with strong entrepreneurial roots work
across these three sites. They combine their expertise in immuno-oncology, stem
cells, and cell-signaling with their knowledge of bispecific antibodies,
antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to
discover and develop novel cancertreatments. This position is based at
Stemcentrx, AbbVie's South San Francisco, CA location.



POSITION DESCRIPTION:


Scientist/Senior Scientist – Assay Development – Antibody
Discovery

As part of a talented and
multi-disciplinary team advancing exciting new approaches to drug discovery and
development, AbbVie
Stemcentrx is looking for a highly motivated scientist with experience in assay
development, specifically with a focus on antibody drug conjugates. This role
is based at Stemcentrx and will contribute to a world-class team in identifying novel
cancer stem cell targets and developing targeted antibody drug conjugate (ADC)
therapies in oncology. The successful candidate willbring extensive knowledge of multiple
assay platforms and strategies to an existing team of highly skilled and
motivated scientists.

Responsibilities



  • Support target discovery and validation efforts
    by
    independently developing and performing assays to evaluate biologic drug
    candidates, often using cell-based and ELISA assays
  • Support development efforts by designing and conducting IND enabling
    experiments, reagent antibody screening, potency, PK, and immunogenicity assay
    development
  • Design
    and implement In vitro assays to explore target biology and mechanisms of
    actions
  • Proactively seeks out and incorporates novel ideas in
    line with the group’s strategy to better characterize our antibody targets, toxins and ADCs
  • Draft IND and patent
    documents and occasionally present at scientific conferences and symposiums
/

Requirements

  • BS or equivalent education with 7+ years of experience or MS or
    equivalent education 5+ of experience.

  • Highly motivated, goal oriented and independent scientist with proven
    technical expertise in development of novel assays

  • Demonstrated ability to independently design, execute and interpret
    critical assay development experiments to further ADC development

  • Strong expertise in antibody biology and characterization

  • Experience with cell imaging systems, flow cytometry, Luminex and
    MSD assay platforms.

  • Prior experience with ADCs; pharmacokinetic,
    immunogenicity and potency assays preferred

  • Excellent oral and written communication skills and a proven track
    record of working effectively in a dynamic, collaborative, team-oriented
    setting