Scientist II - Gaithersburg, MD | Biospace
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Scientist II

MedImmune, LLC

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Location:
Gaithersburg, MD
Posted Date:
9/25/2017
Position Type:
Full time
Job Code:
R-013842
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

Location:
Gaithersburg, Maryland, United States
Job reference: R-013842
Posted date: Sep. 08, 2017

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Scientist I in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

MedImmune seeks an innovative and highly motivated, industry-experienced ScientistII to join the Immune Oncology (IO) team.  You will be responsible for supporting and/or leading multiple IO projects and workstreams from discovery through clinical support, and may have the opportunity to identify and validate new immunomodulatory target using cutting-edge technologies and novel approaches to enrich our IO pipeline. Expertise in areas of human innate immune cells such as dendritic cells, macrophages and a strong scientific background, including high impact publications documenting original discoveries, is required. 

Your duties in this position will involve supporting and/or leading a multidisciplinary team to develop IO biologics for cancer therapy, and utilizing in vitro human primary cell-based immunoassays and possibly in vivo mouse models to elucidate mechanism of action of these agents.  In addition, you will initiate novel, target-related biological research in tumor immunology to identify biomarkers of disease pathogenesis and activity of targeted therapies. Your position will involve leadership, bench-level and supervisory roles, as well as cross-functional activities with other scientists to advance IO programs in our oncology portfolio.

Requirements

Essential Requirements

  • Ph.D. and/or, M.D./Ph.D degree in Immunology or a closely related field
  • Minimum 2-5 years of experience with the development of IO biologics for cancer therapy in the biotech/pharmaceutical industry
  • Proven track-record in preclinical drug development and multiple high impact factor scientific publications
  • Strong written and oral communication skills, self-motivated, innovative, demonstrate leadership
  • Possess an exemplary record of success in research, as evidenced by project advancement, publications and/or patents.
  • In-depth and hands-on expertise in human tumor immunology, immunometabolism biology, in vitro assay development and flow cytometric analysis of human, monkey and mouse immune cells.
  • Able to work both independently and collaboratively in a matrixed environment to design, execute, interpret and communicate pharmacology studies for one or more IMT projects utilizing good scientific judgment and strong team skills.  
  • Experience in four or more of the following:  
    • tumor immunology
    • immunometabolism 
    • epigenetics
    • drug development 
    • characterization of immunomodulatory therapies
    • team leadership
    • cellular or molecular immunology
    • multicolor (>10 parameter) flow cytometric analysis 
    • high-throughput, gene expression and proteomic systems and analytical techniques for large datasets
    • data interpretation

Desirable Requirements

  • Experience with in vivo cancer models (syngeneic, autochthonous and/or xenograft), development of novel tumor immunology models and/or mouse models using model antigens for studying tumor immunology
  • Familiarity with non-human primate immunology

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by lawAstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.