Scientist I - Translational Science - Mountain View, CA | Biospace
Get Our FREE Industry eNewsletter

Scientist I - Translational Science

MedImmune, LLC

Apply
Location:
Mountain View, CA
Posted Date:
7/22/2017
Position Type:
Full time
Job Code:
R-008839
Salary:
Required Education:
Masters Degree
Areas of Expertise Desired:

Job Description

                             
                                       Location:Mountain View, California, United States
Job reference: R-008839

Posted date: Jun. 08, 2017

                                                     
                           


 

   If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.  

   MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Scientist I – Translational Science in Mountain View, CA, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.  

And we’re excited to share that our work at the Mountain View site (along with some other AstraZeneca Group Companies in the Bay Area) will relocate to South San Francisco by Q1 of 2018.  
Click here
for more information on this new facility.

   We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.  

   MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.  

   Main Duties and Responsibilities  

   The Clinical Pharmacology and DMPK Department within Translational Science at Medimmune is seeking a highly motivated individual with expertise in bioanalytical assay development and GLP bioanalysis. You will provide bioanalytical support for preclinical and clinical studies of biotherapeutics across multiple therapeutic areas (Oncology, Autoimmunity, Infectious Disease, Cardiovascular).  Your job responsibilities will include development, validation, and performance of immunoassays and cell-based assays for quantification of drug levels, assessment of immunogenicity, and measurement of relevant biomarkers in biological matrices.    

 

   In this role, you will:  

       
  •      Serve as a bioanalytical lead on cross-functional teams supporting the development of biotherapeutics pipeline    
  •    
  •      Design bioanalytical strategies supporting pre-clinical and clinical development of biotherapeutics    
  •    
  •      Develop immuno- and/or cell-based- assays for determination of drug substances, anti-drug antibodies and biomarkers.    
  •    
  •      Utilize creative and analytical capabilities to troubleshoot challenging assays    
  •    
  •      Design and execute assay qualification and validation    
  •    
  •      Prepare validation protocols, validation reports, bioanalytical reports and Standard Operating Procedures    
  •    
  •      Function as Responsible Bioanalytical Scientist for non-clinical and clinical studies    
  •    
  •      Conduct bioanalytical sample analysis and data review in a GLP-compliant laboratory    
  •    
  •      Evaluate and implement new technologies to expand capabilities and enhance efficiencies    
  •    
  •      Manage CROs for method transfer, validation, sample analysis and report generation    
  •    
  •      Coordinate timelines for activities in collaboration with project management    
  •    
  •      Present results at internal and external meetings    
  •    
  •      Train and mentor junior members in a matrix environment    
  •  

Requirements

   Essential Requirements  

       
  •      Ph.D or advanced degree in Biological Sciences or related field      
  •    
  •      Minimum of 2 years of industry experience, with minimum 8-10 years total relevant experience    
  •    
  •      Expertise with immuno- and cell-based assay development and validation in human biological matrices such as whole blood, serum and plasma    
  •    
  •      Experience in bioanalysis in a GLP compliant environment    
  •    
  •      Experience in CRO management or work in CRO environment    
  •    
  •      Experience with high sensitivity ligand binding platforms    
  •    
  •      Experience with imaging (ImageXpress Micro) or BD flow cytometry platforms    
  •    
  •      Knowledge and experience with GLP requirements and practices    
  •    
  •      Proficiency with spreadsheet, word processing, and graphical computer programs (MS EXCEL, MS WORD, Graphpad Prism, for example)    
  •    
  •      Detail oriented with excellent organizational, documentation and technical writing skills    
  •    
  •      Creative and critical scientific thinking    
  •    
  •      Highly proficient interpersonal communication skills, both verbal and written    
  •    
  •      Ability to work independently and in a team environment with minimal supervision    
  •  
   Desirable Requirements  
       
  •      Experience writing IND- or BLA- supporting reports    
  •    
  •      Experience with viral neutralization assays    
  •    
  •      Experience with Bravo automation    
  •    
  •      Experience with PBMC processing and ELISPOT    
  •    
  •      Familiarity with multiple ligand-binding and flow cytometry technology platforms    
  •  

   Next Steps – Apply today!  

 

   To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.  

   AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.  

   ~bsp  

 

   *LI-MEDI