Scientist I/Scientist II - Gaithersburg, MD | Biospace
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Scientist I/Scientist II

MedImmune, LLC

Gaithersburg, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Masters Degree
Areas of Expertise Desired:

Job Description

Gaithersburg, Maryland, United States
Job reference: R-012517
Posted date: Aug. 15, 2017

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Scientist I or Scientist II in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

The role will be to establish analytical tools and protein product understanding required for development and progression of therapeutic proteins from research, to clinical development to commercialization. 

Day to day responsibilities include designing and executing detailed characterization of protein products, including product variant isolation / enrichment and characterization, identification of protein degradation pathways, structure-functional analysis, and determination of critical quality attributes. Responsible for development and optimization of analytical methods and testing to progress development of therapeutic proteins. Represent the analytical development group on analytical method transfer and validation teams at commercial QC lab. Make detailed experimental observations, review and analyze data, and interpret results.  Author technical reports and regulatory filings. Work with CMC team to support manufacturing process and formulation development. Present scientific data to both internal audiences and external scientific colleagues.  Follow SOPs, policies, and regulations, and perform routine lab equipment maintenance.


Essential Requirements

Must have a MS or Ph.D. or equivalent in Chemistry, Biochemistry or a related field. PhD degree with 0-3 years for Scientist I and 3-7 years for Scientist II. MS degree with 4-8 years for Scientist I and 6-10 years for Scientist II.

Individual must also have a strong understanding of biochemistry and protein chemistry. Experience in chromatography and electrophoresis method development for protein analysis (eg using RPHPLC, IEC, HIC, capillary electrophoresis). Experience in the design and execution of protein structure/function studies. Analytical method tech transfer, qualification and validation experience. Possess excellent verbal and written skills. Effective and collaborative cross-functional team member in a fast-paced environment. Good multi-tasking, time management and organizational skills are essential.

Desirable Requirements

Knowledge with GMP and GLP, is plus.

Experience in an industrial analytical lab working with therapeutic proteins are desirable.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.