Scientist I (NCI) - Frederick, MD | Biospace
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Scientist I (NCI)

Leidos Biomedical Research, Inc.

Frederick, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Research, Scientist,

Job Description

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish National Cancer Institute (NCI) research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers.

This position is a two (2) year assignment with the potential to be extended

The Scientist I work with a team of scientists at the CRTP and collaborators at the Beatson Institute to develop and validate quantitative cell-based assays to be used in a drug development effort to target oncogenic KRAS.  The successful candidate should have a broad understanding of cancer genetics, biochemistry, cell biology and growth factor signal transduction pathways and a strong publication track record demonstrating independence and innovative research.

Responsibilities will Include:
Implement cutting edge technologies to develop novel biological assays to interrogate RAS-effector protein-protein interactions and assess small molecule mechanism of action in KRAS mutated cancer cells
Work in collaboration with multiple functional groups within the CRTP to progress projects, including molecular biology, bioinformatics, and biophysics, as well as external collaborators
Propose, initiate and develop new projects to understand the basic biology and strategies to treat KRAS mutated cancers  


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
PhD in a field related to biochemistry, cell biology, genetics, or in a related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) appropriate to biomedical research, or eight (8) years of experience in lieu of degree
No work experience beyond the Doctorate is required
Tissue culture experience
First author publications in cancer biology, oncology drug discovery or a related field
Must have excellent oral and written communication skills
Ability to efficiently manage workload over multiple projects
Must be able to obtain and maintain a Security Clearance
Candidates with these desired skills will be given preferential consideration:
Small molecule drug discovery
Molecular biology
Cellular assay development
Fluorescence microscopy
Familiarity with RAS and cancer signal transduction pathways
Cancer genomics