Scientist I/II, Protein Characterization - Gaithersburg, MD | Biospace
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Scientist I/II, Protein Characterization

MedImmune, LLC

Gaithersburg, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Masters Degree
Areas of Expertise Desired:

Job Description

Gaithersburg, Maryland, United States
Job reference: R-005426
Posted date: Sep. 14, 2017

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Scientist I/II, in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

You will be expected to design and execute detailed characterization of protein, including product variant isolation / enrichment and characterization, identification of protein degradation pathways, structure-functional correlation, and determination of critical quality attributes. You will be responsible for development and optimization of analytical methods and testing to progress development of therapeutic proteins.  Make detailed experimental observations, review and analyze data, and interpret experimental results.  You will author technical report and regulatory filings for clinical trials and marketing applications. Provide cross-functional support to formulation development, upstream and downstream development.  Represent the analytical development group on analytical method transfer and validation teams at commercial QC lab.  Represent the analytical development group on CMC team.  Present scientific data to both internal audiences within the company and external scientific colleagues. Follow SOPs, policies, and regulations, perform lab experiments, and maintain equipment .


Essential Requirements

BS Degree in Chemistry, Biochemistry or a related field with ten to sixteen years of experience or MS Degree in Chemistry, Biochemistry or a related field with eight to ten years of experience or Ph.D. Degree in Chemistry, Biochemistry or a related field with one to five years of experience

Desirable Requirement

•Experience in an industrial analytical function working with therapeutic proteins characterization are highly desirable.

•Strong understanding of biochemistry and protein chemistry
•Working experience with HPLC, UPLC instruments from different vendors.

•LC method developments (RPLC, Affinity, HILIC, glycan analysis).

•Experience with LC-MS for protein characterization such as peptide mapping, intact mass analysis.

•Familiar with electrophoresis methods such as cIEF, CGE, and instrument operation. 
•Good multi-tasking, time management and organizational skills are essential
•Possess excellent verbal and written skills
•Effective and collaborative cross-functional team member in a fast-paced goal-oriented environment

•Knowledge of QbD concept and biostatistics tools for method optimization.
•Familiar with JMP or other software

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law