Scientist I/II, Process Sciences - South San Francisco, CA | Biospace
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Scientist I/II, Process Sciences

CytomX Therapeutics, Inc.

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Analytical Chemistry, HPLC, Mass Spectrometry, Oncology, Process, Protein Chemistry, Scientist,

Job Description

CytomX Therapeutics is unlocking the potential of antibody therapeutics in oncology by developing a novel therapeutic antibody class of highly targeted Probody™ therapeutics.  

We seek a highly motivated individual to support the protein/antibody characterization needs for all discovery and development programs at CytomX. The successful candidate will work as a bench Scientist I/II in the Process Sciences Department and contribute to the analytical method development needs of the company. This position reports to a Senior Scientist II in the department.


•   Develop HPLC (RP-HPLC), capillary electrophoresis and ELISA based analytical methods for protein/antibody characterization
•   Serve as investigative lead on potential new Probodies, PDCs and Bispecifics programs with respect to analytical methods (including but not limited to RP-HPLC, Ion exchange, SEC and HIC)
•   Apply scientific principles, current technologies, and personal experience to design and execute appropriate experiments to solve a given problem.
•   Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities
•   Maintain and troubleshoot analytical instrumentation as required
•   Troubleshoot assay performance as needed
•   Guide junior staff in development work
•   Independently evaluate literature to propose strategic ideas for analytical method development for Probodies, PDCs and bispecifics
•   Document experimental work in notebooks, SOPs and reports
•   Communicate results and propose scientifically based recommendations


•   PhD in Biochemistry, Analytical Chemistry or related discipline with 0-7+ years of experience in the biotechnology industry; MS in Biochemistry, Analytical Chemistry or related discipline with 10+ years of experience in the biotechnology industry; BS in Biochemistry, Analytical Chemistry or related discipline with 15+ years of experience in the biotechnology industry
•   Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion); working knowledge of GC, GC/MS, LC/MS is highly desirable
•   Strong analytical and critical thinking skills with the ability to interpret complex data
•   Ability to guide junior staff in method development work; previous supervisory experience preferred
•   Highly motivated to learn and support the drug development efforts at CytomX
•   Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude
•   Excellent written and verbal communication skills
•   Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
•   Must be well organized, have a strong work ethic and be diligent in data documentation

CytomX is an equal opportunity employer. Employment decisions are based on merit and business needs. CytomX will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.