If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a Scientist I – Cancer Biology in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.
We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent. Main Duties and Responsibilities
As Scientist I – Cancer Biology, you will work in the laboratory as member of a group investigating novel cellular and molecular mechanisms in immuno-oncology by employing the most relevant cellular in vitro human systems and animal models, when applicable. Additionally, you will support preclinical drug discovery programs, through validation assays required for the selection and functional characterization of new lead monoclonal antibodies. You will also play a significant role in the development of a neo-antigen discovery platform, interrogating the combinatorial effect of cytokines and chemotherapeutics on the tumor proteome, the immune proteasome and how these factors combine to alter the MHCI presented immunological epitope repertoire. You will also be expected to manage and prioritize a number of different projects and tasks in line with the objectives of the group.
- Ph.D. in Immunology
- Two to Four years of post-doctoral experience in a relevant research area or Three to Five years of experience in immunological research
- Extensive scientific expertise in Immunology
- Proven ability to publish in peer reviewed journals, generate technical report summaries and protocols
- Ability to communicate clearly and candidly at internal and external scientific meetings
- Strong hands-on skills in basic biochemical methods including multi-color (6-10 channels) flow cytometry (FACS), FACS-based cell sorting, ELISA/multiplex assays, ELISPOT, western blotting, immunoprecipitation
- Dexterous to develop in vitro cell-based assays (use of primary tissues and cells, functional in vitro assays including cell proliferation, apoptosis, ADCC, cell intracellular signaling pathways, etc.)
- Good experience on multicolor confocal microscopy
- Well-acquainted with molecular biology techniques (i.e., qRT-PCR) and knowledge in genomics and proteomics database analyses
- Highly motivated, innovative, creative, well organized and able to work independently when designing and executing the assays.
- Experience with in vivo tumor models.
Next Steps – Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.