The Bioinformatics Group supports the DNS drug discovery process by: 1) building innovative tools to support the drug discovery process; 2) designing and implementing scientific algorithms to analyze data; 3) providing support to project teams such as our in-house target discovery team.
The Bioinformatics Scientist will have broad hands-on experience in bioinformatics with strong problem solving skills and an aptitude for learning and implementing emerging technologies. The candidate should have a strong interest in pathways construction and analysis as well as statistical/probabilistic inference. The candidate will have shown success in both applying and developing bioinformatics tools for applications such as, but not limited to:
- Computational biomodeling of pathway and biological systems and/or systems biology
- Knowledge of public pathway databases and other biological datastores
- Statistical analysis techniques
Knowledge and experience in these additional areas would also be desirable:
- High-performance computing
- Gene expression profiling
- Text mining
- Computational genomics for prediction of genomic features such as TF binding site prediction, microRNAs, phosphorophylation prediction, etc.
- Machine learning, and programming/scripting experience to contribute to the development of statistical models
- Experience within the Neurobiology domain is a plus
- High content screening
Finally, in addition to solving scientific problems, the Bioinformatics Scientist will also participate in informatics infrastructure design / implementation. To accomplish these tasks, a strong software background is required. The ideal candidate will have a set of software skills similar to:
- Unix and Unix Shell
- Good understanding of RDBMS concepts
- Development experience in Oracle, PostgreSQL and/or MySQL
- Exp. in Java, PERL, Python, UNIX Shell, Groovy or other languages
- Expertise in Object-Oriented Analysis and Design
- Knowledge and implementation experience of GOF design patterns.
- Knowledge of service oriented architecture (SOA) principles
- Experience in developing web services
- UI Design and Development experience
- Ability to develop UI Standards and Style Guides
- Experience with CSS and HTML
- Semantic Web Technologies
- Schema Design / Data Modeling
- Data Transformation / ETL
- A B.S. degree in computer science and/or life sciences required. M.S. or Ph.D. in bioinformatics, computer science and/or life sciences preferred. Industry experience is also a plus.
-Ability to work independently and ability to interact with a multidisciplinary team of medicinal chemists, biologists, pharmacologists and external collaborators.
-Ability to evaluate intangible variables, requiring regular use of ingenuity and creativity.
-Strong written and verbal communication skills, with an ability to contribute to scientific literature and conferences through publication and presentation of research results.