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Scientist - Bioinformatics, Pathway Specialist

Dart NeuroScience LLC

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Location:
San Diego, CA
Posted Date:
12/15/2014
Position Type:
Full time
Job Code:
14-009 #0137
Salary:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

The Bioinformatics Group supports the DNS drug discovery process by: 1) building innovative tools to support the drug discovery process; 2) designing and implementing scientific algorithms to analyze data; 3) providing support to project teams such as our in-house target discovery team.
The Bioinformatics Scientist will have broad hands-on experience in bioinformatics with strong problem solving skills and an aptitude for learning and implementing emerging technologies.  The candidate should have a strong interest in pathways construction and analysis as well as statistical/probabilistic inference.  The candidate will have shown success in both applying and developing bioinformatics tools for applications such as, but not limited to:
-   Computational biomodeling of pathway and biological systems and/or systems biology
-   Knowledge of public pathway databases and other biological datastores
-   Statistical analysis techniques

Knowledge and experience in these additional areas would also be desirable:

-   High-performance computing
-   Gene expression profiling
-   Text mining
-   Computational genomics for prediction of genomic features such as TF binding site prediction, microRNAs, phosphorophylation prediction, etc.
-   Machine learning, and programming/scripting experience to contribute to the development of statistical models
-   Experience within the Neurobiology domain is a plus
-   High content screening

Finally, in addition to solving scientific problems, the Bioinformatics Scientist will also participate in informatics infrastructure design / implementation.  To accomplish these tasks, a strong software background is required.  The ideal candidate will have a set of software skills similar to:
- Unix and Unix Shell
- Good understanding of RDBMS concepts
- Development experience in Oracle, PostgreSQL and/or MySQL
   - Exp. in Java, PERL, Python, UNIX Shell, Groovy or other languages
   - Expertise in Object-Oriented Analysis and Design
   - Knowledge and implementation experience of GOF design patterns.
   - Knowledge of service oriented architecture (SOA) principles
- Experience in developing web services
   - UI Design and Development experience
   - Ability to develop UI Standards and Style Guides
   - Experience with CSS and HTML
   - AJAX / JavaScript programming
- Semantic Web Technologies
- Schema Design / Data Modeling
- Data Transformation / ETL

Requirements

- A B.S. degree in computer science and/or life sciences required.  M.S. or Ph.D. in bioinformatics, computer science and/or life sciences preferred.  Industry experience is also a plus.
-Ability to work independently and ability to interact with a multidisciplinary team of medicinal chemists, biologists, pharmacologists and external collaborators.
-Ability to evaluate intangible variables, requiring regular use of ingenuity and creativity.
-Strong written and verbal communication skills, with an ability to contribute to scientific literature and conferences through publication and presentation of research results.

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