Scientist, Analytical Method Development and Characterization (Biologics) - San Francisco, CA | Biospace
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Scientist, Analytical Method Development and Characterization (Biologics)

Nektar Therapeutics

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Location:
San Francisco, CA
Posted Date:
9/14/2017
Position Type:
Full time
Job Code:
Salary:
Fair Market
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Analytical Chemistry, Validation,

Job Description

Summary:

Scientist, Biologics Analytical Development, part of Nektar Biologics CMC organization is responsible for product characterization, analytical method development/validation of proteins and protein-conjugates for Nektar Biologic products in pre-clinical and clinical development stages.  Conducts and collaborates with others on analytical issues relevant to long-term objectives and concerns. Develops testing methodologies to support process development of drug substance and drug product.

The successful candidate will be responsible for:
•   Develop and validate analytical methods to support early stage drug development activities
•   Characterize protein polymer conjugates to elucidate conjugate sites and distribution
•   Assist process development scientists to characterize and monitor in-process purification
•   Transfer analytical methods to internal QC group or CRO for drug substance and drug product release testing
•   Summarize experimental data and write technical reports

This position contributes to and supports the company’s research development and manufacturing to create high value therapeutics to address unmet medical needs.

Responsibilities:

Additional responsibilities include:
•   Use professional concepts and company's policies and procedures to solve a wide range of difficult problems in imaginative and practical ways
•   May determine methods and procedures on new assignments and recommend new methods and procedures
•   May provide guidance to other lower level personnel  
•   Communicate cross-functionally with groups such as research, process development, formulation development, manufacturing, QC group and CRO/CMO to ensure appropriate project support
•   Maintain a current knowledge of latest technological/scientific trends

Requirements

Requires a PhD in a scientific discipline and a minimum of 2+ years related experience, may include post-doctoral experience.  Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered.
•    Must have in-depth knowledge and hands-on experience in analytical method development and characterization for biologics
•   Must have extensive experience in different HPLC separation methods such as ion exchange, reversed phase, and size exclusion chromatography for proteins Must be able to demonstrate potential for technical proficiency, scientific creativity, collaboration with others and independent thought  
•   Must be able to clearly communicate scientific information both written and oral.
•   Experience in mass spectrometry and capillary electrophoresis analysis of proteins is highly desirable
•   Works on problems of moderate scope in which analysis of situation or data requires a review of identifiable factors
•   Experience in technology transfer to internal QC lab or CRO in support of drug substance/drug product release testing is highly desirable
•   Good computer skills are required. Working knowledge of MS word, Excel, Power point is a plus
•   Must be willing to work as part of a team