Research Scientist – Gene Editing, Biology - South San Francisco, CA | Biospace
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Research Scientist – Gene Editing, Biology

Christine Mathews Consulting

South San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Biochemistry, Biology Research, Biomedical, Biotechnology, Cell Biology, Drug Discovery,

Job Description

Trucode Gene Repair Inc. is pioneering a novel synthetic gene editing technology to treat and cure patients with devastating rare diseases. We seek a highly skilled, motivated and creative scientist ready to function in a fast-paced and collaborative environment.  Candidates should have exceptional cell and molecular biology training.  The successful candidate will be part of a fast-paced, dynamic, and rewarding work environment, where the abilities to effectively communicate and function in a team environment will be essential for success.


•   Design and perform cell-based gene editing studies
•   Hands-on execution of in vitro and ex vivo assays to analyze on- and off- target effects of gene editing using novel therapeutic agents
•   Perform cell biology, molecular biology, and biochemistry analyses
•   Analyze, interpret, and present experimental data
•   Collaborate with colleagues to ensure timeline adherence and project alignment to meet group and company goals
•   Support external and internal projects via team meetings, presentations, and reports


Essential Qualifications

•   PhD degree or equivalent with at least 3 years of post-doctoral training or industry experience.
•   Very strong background in molecular biology and genetics
•   Hands-on experience with current cell and molecular biology techniques
•   Experienced with mammalian cell culture (primary cell culture, cell line), transient transfections, and cell-based assays
•   Team player, and a clear communicator
•   Close attention to detail and record keeping
•   Ability to operate independently and readily adapt to change

Preferred Qualifications

•   Familiarity with the field of hematopoiesis and hematological diseases
•   Experience manipulating primary human hematopoietic cells
•   Experience with mammalian gene therapy/editing (CRISPR/Cas9, ZFNs, TALENs) , RNA biology, DNA repair, or DNA/RNA/protein delivery
•   Knowledge in DNA repair mechanisms and pathways
•   Experience with digital PCR, NGS
•   Experience in FACS, Luminex multiplex assay, microarray analysis, and bioanalytics
•   Experience with IHC/ICC/IF