Research Associate, Structural Biology - San Diego, CA | Biospace
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Research Associate, Structural Biology

Dart NeuroScience LLC

San Diego, CA
Posted Date:
Position Type:
Full time
Job Code:
16-027 #784323
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Associate, Protein, Research, Structural Biology,

Job Description

DNS is seeking an energetic and highly motivated Research Associate to join the protein production group within the Structural Biology department.  The candidate will work as part of a team of scientists to support the recombinant production of proteins in milligram-scale quantities for macromolecular crystallographic studies.  Major responsibilities will include protein expression in E-coli, insect cell-baculovirus and mammalian cell systems; maintenance of cell lines and cell culture facility; and high throughput expression screening and small/midi scale protein purification. The candidate will be working in a creative, dynamic environment and will be required to work with limited guidance in a team-oriented manner.  The candidate is required to closely interact with molecular biologists and protein chemists in the group and must have strong interpersonal skills.


• A BS or MS in life science, with 2+ years of relevant experience in recombinant protein expression, preferably in an industrial setting.
• Proven hands-on experience in recombinant protein expression in prokaryotic (E-coli) and Eukaryotic (baculovirus/mammalian) expression systems. Hands-on experience in insect cell culture and transfection. Experience in biophysical/biochemical protein characterization (Western blot, SDS-PAGE, MassSpec and chromatography).
• Knowledge of principles of recombinant protein expression in prokaryotic and eukaryotic systems. Knowledge of fundamentals in protein chemistry and biophysical/biochemical protein characterization. Background knowledge in structural biology or membrane protein science is an advantage.
• Demonstrated independent thought/creativity in science. Excellent collaboration, organizational, communication (oral and written) and multitasking skills.
• Must be willing to work flexible hours and to meet project timelines.