Research Associate, Protein Science - Brisbane, CA, CA | Biospace
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Research Associate, Protein Science

Harpoon Therapeutics, Inc

Brisbane, CA, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Associate, Biochemistry, Biology, Biotechnology, Cell Culture, Molecular Biology, Protein, Protein Chemistry, Protein Purification, Research, Research Associate: Cell Biology,

Job Description

Harpoon Therapeutics is a startup biotechnology company located in Brisbane, CA.  We are focused on the development of novel immune cell engaging therapeutics for oncology indications.  We are looking for a motivated, flexible, highly productive individual, who is seeking a dynamic fast-paced cross-functional collaborative research environment. As an integral member of the Protein Science group, this individual will be primarily engaged in purification and analysis of proteins.

Key Responsibilities

-    Buffer and sample preparation, execution of multi-step protein purification by diverse chromatographies using AKTA Unicorn-based methods
-   SDS-PAGE, spectrometry, HPLC analysis of purified proteins
-   Protein chemistry, conjugation, and validation of reagent molecules for assays
-   Materials management and database maintenance
-   Most qualified candidates could engage in HPLC, Light scattering and Fluorescence-based experiments to evaluate protein stability to aid in selection of the best therapeutic molecules.
-   May include some mammalian cell culture, transient or stable expression of proteins and titer qualification: SDS-PAGE, Western blot, Octet-based methods.
-   Maintain records, prepare reports, make regular presentations to summarize results and update management.


The ideal candidate will have:
-   Training in Molecular Biology, Biochemistry or related fields, with a Bachelors + 3-5 years’ or a Masters + 1-3 years’ relevant experience.
-   Demonstrated experience in routine protein chemistry including purification and conjugation. Some analytical HPLC experience desired, Agilent systems preferred.
-   Experience in mammalian cell culture toward protein expression highly desired.
-   Excellent verbal and written communication, strong organizational and interpersonal skills.
-   Aptitude for learning new laboratory techniques and handling diverse tasks concurrently.
-    Ability to work independently or with limited direct supervision.
Please reference Job #HT17-003