Research Associate II, Functional Biology - San Diego, CA | Biospace
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Research Associate II, Functional Biology

AnaptysBio, Inc.

San Diego, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Allergy & Immunology, Antibody, Assay, Assay Development, Associate, Biology, Biology Research, Biomarker, Biotechnology, Cell Biology, Dermatology, Drug Discovery, Elisa, Flow Cytometry, Immunology, Research,

Job Description

Position Summary
You will assist in developing, performing, and interpreting a wide range of assays to aid therapeutic antibody characterization and development as candidates for severe human diseases. These may include in vitro and/or ex vivo cellular functional and signaling assays using primary human, primate, and/or mouse cells and cell lines, as well as characterization of antibody pharmacokinetics and pharmacodynamics.  May also be responsible for conducting biomarker assays to support preclinical and clinical programs.  Specific responsibilities include:
•   Develop, optimize, and perform ELISA and flow cytometry assays in support of antibody programs
•   Perform cellular functional and signaling assays using primary mouse, monkey or human cells and cell lines to evaluate cellular activity of candidate antibodies against specific targets
•   Execute on biomarker strategies for one or more projects, in collaboration with Discovery and Clinical development team members
•   Design and accurately execute experiments, analyze and interpret experimental results contributing to research program strategies
•   Organize, summarize and present data to supervisor and at project team meetings
•   Interact as needed to coordinate hand-off of materials or protocols between cell biology and molecular biology or protein sciences
•   Prepare technical reports, summaries, and detailed protocols.


•   Bachelors’ degree in a biology-related discipline and 2-5 years related laboratory experience or Masters’ in a biology-related discipline with 1-3 years related laboratory research experience
•   Functional knowledge of, and working experience in, principles and practices of cell biology methodologies and cellular immunology, including mammalian cell culture, cell transfection, functional/in-vitro cellular immunology assays and cellular assay development
•   Proficient in performing ELISA based assays, and familiar with assay development and implementation
•   Experience in executing cellular signaling assays including ELISA, luminescence, and flow cytometry-based readouts
•   Experience in primary mouse, monkey, or human lymphocyte and mononuclear cell purification and functional assays
•   Able to design and conduct experiments to answer specific scientific questions, and recognize need to modify protocols/procedures with limited supervision
•   Able to learn new laboratory techniques efficiently, troubleshoot experiments, and ensure experiments are well designed and performed to a high standard
•   Ability to maintain productivity and quality results for routine, established assays, troubleshooting as necessary
•   Ability to communicate clearly, and to report and present experimental results and analysis to supervisor and department colleagues
•   Effective interpersonal skills; team player with the ability to work effectively with matrixed colleagues, intensely committed to success and getting the job done well in a highly dynamic environment
•   Ability to organize assignments and work within schedules and deadlines
•   Position may require occasional evening and/or weekend commitment
•   Position may require working with biological and/or chemical hazards
•   Position might require lifting up to 20 pounds