Research Associate/Associate Scientist, Structural Biology - San Diego, CA | Biospace
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Research Associate/Associate Scientist, Structural Biology

Dart NeuroScience LLC

San Diego, CA
Posted Date:
Position Type:
Full time
Job Code:
16-019 #779074
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Protein Chemistry, Protein Purification, Structural Biology,

Job Description

DNS is seeking a motivated Research Associate for the Structural Biology Department. The candidate is required to have a broad technical background and experience in state-of-the-art protein purification and characterization processes necessary to establish procedures that reproducibly lead to the generation of high quality protein for NMR and crystallography structural studies. Major responsibilities will include hands-on experimental work to support protein expression, purification, protein labeling for NMR studies, biophysical protein characterization, crystallization and NMR technical support.

The candidate will be working in a creative, dynamic environment and will be required to be team-oriented with a desire to proactively seek out and implement new technologies to improve construct design, expression, purification and characterization of proteins for 3D structural studies and NMR-based screenings/assays. The candidate must have excellent interpersonal skills and must be organized, neat and timely with regard to data generation, meeting presentations and study reports.


• A BS with 2-4+ years of relevant experience in protein purification and characterization, preferably in an industrial setting, or MS in life science.
• Proven in-depth knowledge and hands-on experience in different protein purification methods (e.g affinity, size-exclusion, ion-exchange, isoelectric focusing chromatography) and biochemical/biophysical characterization techniques (e.g., Western blot, SDS-PAGE, thermal melting, mass spectrometry of protein and small molecules, assay development). Prior knowledge of working with membrane protein is highly desirable.
• Experienced with a variety of protein labeling techniques in eukaryotic and prokaryotic expression systems and hands-on experience with NMR sample preparation in HT mode is highly desirable.
• Demonstrated independent thought/creativity in science. Excellent collaboration, communication (oral and written) and multitasking skills and able to present work formally to Scientific Research Committees.