DNS is seeking a motivated Research Associate for the Structural Biology Department. The candidate is required to have a broad technical background and experience in state-of-the-art protein purification and crystallization processes necessary to establish procedures that reproducibly lead to the generation of crystallization-grade protein and crystals suitable for structural studies. Major responsibilities will include hands-on experimental protein chemistry work to support large scale protein purification, biochemical/biophysical protein characterization and crystallization.
The candidate will be working in a creative, dynamic environment and will be required to be team-oriented with a desire to proactively seek out and implement new technologies to improve construct design, expression, purification and crystallization of proteins for 3D structural studies. The candidate must have excellent interpersonal skills and must be organized and timely with regard to data generation, meeting presentations and study reports.
• A BS or MS in life science, with 2+ years of relevant experience in protein purification and crystallization, preferably in an industrial setting
• Proven in-depth knowledge and hands-on experience in different protein purification methods (e.g affinity, size-exclusion, ion-exchange, isoelectric focusing chromatography) and biochemical/biophysical characterization techniques (e.g., Western blot, light scattering, calorimetry, analytical ultracentrifugation, DLS, thermal melting, protein MassSpec, assay development).
• Proven in-depth knowledge and hands-on experience in the crystallization of proteins and ligand/protein co-complexes using high-throughput crystallization robotics and methods.
• Demonstrated independent thought/creativity in science. Excellent collaboration, communication (oral and written) and multitasking skills and able to present work formally to Scientific Research Committees.