RA/Scientist/Sr. Scientist- Process Development Oligonucleotide Synthesis - Cambridge, MA | Biospace
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RA/Scientist/Sr. Scientist- Process Development Oligonucleotide Synthesis

WAVE Life Sciences

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Location:
Cambridge, MA
Posted Date:
7/25/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Associate, Research, Scientist, Senior Scientist,

Job Description


POSITION RESPONSIBILITIES:

•   Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides to support projects in multiple disease areas.
•   Optimization and scale up of processing methods
•   Supports continuous improvement initiatives by identifying areas needing improvement, recommending strategies for improvement, and helping to implementing those strategies once approved
•   Ability to operate and maintain lab instruments such as AKTA synthesizers, purifiers and HPLC and LC-MS
•   Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
•   Familiarity with pre-clinical drug development and IND-enabling phase of therapeutic programs
•   Collaborative team player who is also proficient at leading projects and motivating teams
•   Capacity to be highly productive in a fluid and fast-paced work environment

Requirements


EDUCATION/EXPERIENCE:

•   PhD in Chemistry, science or engineering with at least 3-5 years of experience in industry environment OR MS in Chemistry or related discipline with at least 3 years of experience in industry environment. (BS 5 Years)
•   Strong knowledge of Oligonucleotide Synthesis, Deprotection and Purification techniques
•   Experience in scale up and technology transfer of processing
•   Experience with the AKTA line of synthesizers
•   Familiarity with analytical techniques and data interpretation HPLC, LC-MS, UV-Vis