Proteomics Lead - Primary Pharmacology Group - Groton, CT | Biospace
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Proteomics Lead - Primary Pharmacology Group

Pfizer Inc.

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Location:
Groton, CT
Posted Date:
1/20/2017
Position Type:
Full time
Job Code:
74534.20993
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

About Pfizer

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.



Role Description

Pfizer colleagues have many perspectives, many backgrounds and many strengths. But we share one goal: to make the world a healthier place. Our investment in people is a commitment to strengthen an already remarkable company. Pfizer is a place for people who strive to learn, grow and lead. Worldwide Research and Development at Pfizer combines research and technology units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies through advancing small molecules and bio-therapeutics, including vaccines.
* This laboratory leader will oversee and advance proteomics technologies in support of the Worldwide Research and Development portfolio, including the design and execution of experiments to enable delivery of the Research Portfolio.
* This leader will play a key role in developing the group strategy and will lead lab-based efforts focused on providing high quality proteomics data in support of cell model characterization and phenotypic screening deconvolution to enable target identification in support of the Worldwide Research and Development portfolio.
* This leader will partner with internal scientists, designing valid experiments to advance knowledge of disease biology, pathway changes, target identification and validation, lead validation, and mechanism of action through proteomics and will also partner with other leaders generating omics data.
* This leader will play a key role in finding innovative ways to integrate proteomics into primary pharmacology screening funnels to advance the early therapeutic portfolio.
* This leader will partner with external vendors to extend the impact, capabilities and capacity of the group.



Responsibilities

The successful candidate will lead a laboratory within the Primary Pharmacology Group which is focused on the design, development, optimization and execution of in vitro plate based screening in support of early stage drug discovery projects led by Research Units. The Primary Pharmacology Group also provides cell model generation and characterization, and target identification/validation expertise, applying physiologically relevant approaches to target-based and phenotypic-based screens for programs to ensure integrated support from idea to candidate selection. The successful candidate must be able to work collaboratively and communicate effectively with various project teams, across scientific disciplines such as chemical biology, molecular biology, computational sciences, ADME and safety to contribute to iterative experimental design and mechanistic hypothesis generation through the interpretation of complex proteomics data. He/she will help develop the group strategy and will lead lab-based proteomic efforts focused on developing and implementing state-of-the-art mass spectrometry-based methods to identify, characterize and quantify proteins from complex protein mixtures such as human or animal cell lysates. The candidate should possess strong collaborative and written/verbal communication skills, and an enthusiastic, optimistic attitude. He/she should demonstrate strong leadership skills, flexibility, a good sense of humor, and be adept at multi-tasking and building relationships. Successful candidates will be expected to: * Provide scientific leadership and partnership across the organization for target identification and validation, using proteomics.
* Provide discovery project teams with high quality proteomics data in support of cell model characterization and phenotypic screening deconvolution to enable target identification/validation and hit identification/optimization.
* Maintain a portfolio of projects that routinely deliver to impact portfolio milestones at various stages from exploratory to clinical candidate selection.
* Liaise closely with partners in the Primary Pharmacology Group, the Research Units and Chemistry to drive screening funnels for target identification and validation, hit identification and validation, biology and pathway understanding and mechanism of action studies, incorporating the use of physiologically relevant cell models as appropriate
* Dive deeply into the science of the portfolio projects. Predict timelines with accuracy and transparency and manage partner expectations appropriately for delivery of results.
* Proactively establish and grow effective partnerships across multiple disciplines (e.g. computational sciences, chemistry, safety and ADME) to advance scientific innovation in the realm of target validation.
* Direct original research aligned with the research priorities established by the Medicine Design strategic goals and Business Plan, stepping up to lead internal science and technology teams as appropriate.
* Possess excellent slide preparation, presentation and general communication skills.
* Maintain a 'cutting edge' awareness of technical developments and scientific advancements in the field and apply these innovatively to advance capabilities and improve performance.
* Continue to build Pfizer's strong external network in proteomics, chemical biology, phenotypic screening to integrate advances at academic centers with our internal strategy and capabilities, and where appropriate to progress precompetitive topics via collaborations and consortia.
* Identify opportunities for externalization of appropriate capabilities; qualify and oversee deliverables from external CROs.
* Adopt a Continuous Improvement mindset to improve quality, efficiency and/or cost of processes within the group.
* Encourage growing use of robotics and automation where appropriate to efficiently optimize processes.
* Guide and develop laboratory-based scientists. Be able to recognize talent, articulate qualities of performance, conduct courageous conversations and develop excellence.
* Take a leadership role in educating/mentoring other scientists within the department and across the organization.
* Oversee documentation compliance of the team.
* Travel as required by the role (regularly to Cambridge MA) to partner with therapeutic teams and additionally to appropriate meetings and conferences.

Requirements

Qualifications

* Minimum qualification PhD in analytical chemistry, biochemistry or equivalent with 5+ years of drug discovery experience in proteomics preferred.
* Prior experience leading a laboratory-based group and working as part of a multi-disciplinary team focused on the discovery of novel therapeutic agents.
* Experience using proteomics for cell model characterization, deconvolution of phenotypic hits leading to target identification and validation.
* Experience using physiologically relevant cell models including use of primary human tissue (normal and disease) in proteomics studies.
* Expertise in quantitative proteomics using techniques such as iTRAQ, TMT and SILAC.
* Experience delivering discovery strategies for target validation and the identification and optimization of small molecule therapeutics in an industrial setting is highly valued
* Demonstrated expertise in building strategies that harness the talent within an organization and provide clear innovative visions for the future built on the foundations of strong business acumen.
* Demonstrated ability to forge strong collaborative relationships and align multidisciplinary goals.
* Have a sustained track record of execution, delivering high quality data on time to meet the needs of project teams.
* Evidence of pushing the boundaries of technologies and innovative thinking.
* Demonstration of excellent computer, verbal and written communication skills.
* Demonstrated strengths in people management, supporting and nurturing talent, delivering results and providing opportunities for growth.
* Demonstrated ability to build networks outside organizational walls and across multiple cultures: academic, industrial, non-profit and CRO sectors. At Pfizer, we believe in helping people lead healthier lives - from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs. The Primary Pharmacology group offers an exciting, fast-paced, supportive environment for colleagues, and fosters a culture encouraging openness, innovation and ownership of our science. We aim to provide continual scientific and growth opportunities for personal development commensurate with a colleague's goals and experience. PHYSICAL/MENTAL REQUIREMENTS Complex analyses, sitting, standing, and walking. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Travel as required by the role (up to Cambridge MA) to partner with therapeutic teams, chemical biology group and computational sciences and additionally to attend appropriate meetings and conferences.



EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.