Protein Chemistry Scientist - San Carlos, CA | Biospace
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Protein Chemistry Scientist

Allakos Inc.

Location:
San Carlos, CA
Posted Date:
9/11/2017
Position Type:
Full time
Job Code:
Salary:
Competitive
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Antibody, Biochemistry, Development, Elisa, Formulation, HPLC, Mass Spectrometry, Molecular Biology, Protein, Protein Chemistry, Protein Purification,

Job Description

COMPANY
Allakos is a clinical-stage company developing antibodies that target receptor molecules present on the surface of immune effector cells involved in allergy, inflammation, tissue damage and proliferative disorders.

POSITION
The company is seeking to recruit a Scientist or Research Associate in Protein Chemistry group within Research and Development department. The candidate will have an opportunity to participate in a dynamic and challenging work environment, and contribute to early and late stage programs.

PRIMARY RESPONSIBILITIES
Purification of proteins and antibodies to support research and development activities:
o   Cell culture supernatant harvest and filtration
o   Protein purification
o   Protein concentration and formulation

Protein analysis and characterization:
o   Soluble aggregates formation (SEC HPLC)
o   Purity and fragments formation (SDS-PAGE)
o   Visible aggregation (UV/VIS spectroscopy etc.)
o   Perform stability studies of purified proteins
o   Protein-protein interaction Biacore, Forte Bio
       and ELISA
o   Protein conjugations and modifications

The scientist or research associate will produce protocols and reports, transfer protocols to CMOs and CROs and actively participate in team meetings.

Requirements

(1)   BSc, Msc or Ph.D. degree in biochemistry,
       protein chemistry, biology, or related scientific
       field
(2)   Minimum of 2 years industry or postdoctoral
       experience
(3)   Experience in protein purification such as
       Protein A, IMAC, ion-exchange and HIC
(4)   Experience in tangential flow filtration
(5)   Analytical techniques such as SDS-PAGE, UV
       spectroscopy, and HPLC
(6)   Proficient use of AKTA, Agilent HPLC, and
       ForteBio systems