Process Chemistry Associate - Oligonucleotide Synthesis - Boulder, CO | Biospace
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Process Chemistry Associate - Oligonucleotide Synthesis

miRagen Therapeuitcs

Boulder, CO
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Biochemistry, Chemistry, Process,

Job Description

miRagen is currently seeking a Process Chemistry Associate I/II (PCA I/II) to conduct routine synthesis and process development. The incumbent will support the development of procedures and protocols leading to enhanced quality, purity, reproducibility, and other cost saving measures. The PCA I/II continually aims to learn new chemistries, techniques, technologies, suppliers and other advancements in oligonucleotide synthesis. Primary responsibilities include:

•   Perform automated synthesis of oligonucleotides on a variety of scales and/or instruments.
•   Assist with synthesis validation and optimization processes.
•   Conduct downstream deprotection and/or other post-synthesis work-up.
•   Ensure compliance with the finished product specifications (e.g. – yield and purity).
•   Assist with instrument maintenance and synthesis reagent tracking.
•   Maintain an electronic lab notebook and other records.
•   Ad-hoc projects as necessary.


Required Knowledge and Skills:
•   Experience in solid phase synthesis of oligonucleotides and modified biopolymers.  
•   Familiarity with DNA/RNA automated synthesizers.
•   ÄKTA OligoPilot experience preferred but not requisite.
•   Experience with laboratory automation desirable.
•   Excellent oral and written communication skills necessary.
•   Proficient with Microsoft Office programs. Experience with ChemDraw desirable.
•   Solid troubleshooting and organizational skills.
•   Must possess the ability to work effectively in a cross-functional team environment.
•   Good time management.