Reports to the Associate Director, Immuno-oncology, working to discover and develop novel therapeutic antibodies for cancer treatment. This scientist will lead therapeutic programs targeting novel immune checkpoint proteins for cancer therapeutics, and will play a role in defining strategy of the programs. In a matrix setting, this scientist will also be responsible for establishing in vitro assays to elucidate the biology of novel immunology targets and to use these assays to identify and characterize lead antibodies to these targets. The position will be asked to supervise research associates and provide scientific mentorship and career growth opportunities for their direct report(s). In this role, the scientist will have the opportunity to have a significant role in the discovery of novel drugs and their effects on target biology in the field of immuno-oncology.
ESSENTIAL JOB FUNCTIONS & ACCOUNTABILITIES :
• Designs, develops and executes cell-based immunology assays for the
identification and characterization of therapeutic antibodies
• Leads and advances therapeutic program by defining strategy and guiding
team members across functions/sites and from corporate partners.
• Advances capabilities of the Antibody R&D group through development of
novel screening strategies or implementation of new technologies
• Provides expertise on flow cytometry based technologies to support Ab
screening and functional analysis of immune cells
• Maintains an up-to-date understanding of the oncology and tumor
immunotherapy literature and methodology, as well as the literature related
to the specific antibody discovery projects
• Presents written and oral reports to the project team, Antibody R&D group,
and management. Communicates research efforts to collaborators,
corporate partners, and/or at scientific meetings.
• Plays a visible role in decision-making process on cross-functional antibody discovery teams; providing core expertise and input on scientific direction
• Supervise research associates and provide scientific and career mentorship
• Develops and contributes to company’s intellectual property domain by way of patents and/or publications.
• Collaborates with scientific colleagues in Tel Aviv
• Ph.D. in Immunology, Pharmacology, Cell Biology, or related life science
• Minimum of 9 years (Principal Scientist) or 6 years (Senior Scientist) of post-
graduate experience is required, preferably in the field of immunology or
• Prior experience with cell-based assays relevant to cancer drug development
and immune functions is a must
• In vivo experience with in vivo models relating to tumor immunology is
• Prior project leadership experience in antibody drug development preferred
• Extensive experience in flow cytometry based technologies is required
• Track record of scientific accomplishment as evidenced by quality and
quantity of publications and/or inventions
• Demonstrated ability to independently manage functional responsibilities on
therapeutic project teams