Principal Scientist, Protein Analytical Development - South San Francisco, CA | Biospace
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Principal Scientist, Protein Analytical Development

Applied Molecular Transport, LLC

Location:
South San Francisco, CA
Posted Date:
7/20/2017
Position Type:
Full time
Job Code:
Salary:
TBD
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

An immediate opening exists for a Principal Scientist, Protein Analytical Development to join the newly formed Analytical Sciences group, reporting to the group Head.  

The primary focus of the position will be executing unique methods required to characterize the chemical and physical properties of AMT’s biological therapeutics, as well as to develop relevant assays to guide downstream protein production method development. This position will be expected to support in vivo PK/PD assessments in a fast-paced environment. The successful candidate can also work directly with vendors or contract laboratories (CROs), supporting drug development, methods and technology transfer.

Requirements

•   A PhD degree in chemistry/biochemistry or related field with 10+ years industry experience in a protein analytical sciences role.

•   Deep experience in sample preparation and analytical techniques for biological products and impurity characterization, to include spectroscopic and photometric methods, chromatographic methods (e.g., GC, Partition, Ion exchange, SEC, HPLC, MS/LC-MS), electrophoretic methods and bioassays.

•   A good understanding and adherence to Good Laboratory Practices and/or Quality Control related cGMPs, as applicable.

•   Hands on and leadership experience to advance biological therapeutics from preclinical to clinical development.
•   Hands-on laboratory experience and skills working with proteins.

•   Solid understanding of the current US/EU regulatory and quality requirements and standards relevant to biologics drugs; experienced in contributing to IND filings.

•   Excellent verbal and written communication skills.

•   Proven ability to present at National/International Scientific Meetings and produce publications in high quality peer-reviewed journals.

•   Team-oriented work style, with effective conflict-resolution and stake-holder management skills.

•   Experience in a successful biopharmaceutical organization, preferably including small companies.

•   Adjustability to changing priorities and timelines with willingness and ability to multi-task.

•   Ability to work independently in a small group setting with limited operational support.

Notes:
•   This position requires candidates to present a scientific presentation in a seminar during the interview.
•   Applicants are expected to include a cover letter highlighting how their qualifications match our needs