Principal Scientist, Biophysics Laboratory - , CA | Biospace
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Principal Scientist, Biophysics Laboratory

Pfizer Inc.

, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

About Pfizer

A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Role Description

The Pfizer Oncology Research Unit in La Jolla is seeking a full-time employee to support the drug discovery process to create innovative cancer therapies. The successful candidate will evaluate drug interactions and protein behavior primarily by label-free methods as a member of the Biophysics Laboratory. In addition, characterization of drug interactions may occur through other biochemical methods. The successful candidate will work with a high degree of independence to provide biophysical insight on targets and ligands as well as impact project teams at a strategic level.


We have an immediate opening in the Pfizer Oncology Research Unit for a highly productive, independent research colleague to join the Biophysics Group. We are seeking a highly-motivated individual with an advanced practical knowledge of characterizing molecular interactions by biophysical methodologies and a growing knowledge of other relevant disciplines. The successful candidate will primarily be responsible for the development and operation of assays for the thermodynamic and kinetic characterization of small molecule-protein and protein-protein interactions. Identification of new biophysical methods is expected in order to provide a leading-edge insight of drug behaviors to the organization. Enzymology experience in elucidating mechanisms of drug action and catalysis is valued. A working knowledge of structural biology will be helpful. Good communication skills (written, verbal), leadership skills, and the ability to work in a multi-disciplinary team environment are essential.



The ideal candidate must have a Ph.D. in a biophysics/biochemistry with 3 - 5 years of experience in drug discovery. The individual will be a technical expert with label-free approaches (e.g. calorimetry, SPR) used to characterize biophysical phenomena (e.g. small molecule-protein interactions, protein stability, protein-protein interactions). Experience in mass spectroscopy, enzymology, and protein purification is beneficial. Publication in top-tier journals is also a prerequisite. The candidate must have good communication skills and be capable of working independently. PHYSICAL/MENTAL REQUIREMENTS Must be able to work safely in a laboratory environment with lab coat, protective eye wear and gloves. The job can requires standing and walking on a daily basis.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.