PostDoc Fellow - Differentiating the effects of myeloid-targeting drugs on the tumor microenvironment by single cell sequencing - Waltham, MA | Biospace
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PostDoc Fellow - Differentiating the effects of myeloid-targeting drugs on the tumor microenvironment by single cell sequencing

AstraZeneca Pharmaceuticals LP

Waltham, MA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

                                       Location:Waltham, Massachusetts, United States
Job reference: R-003859

Posted date: May. 03, 2017



   At AstraZeneca we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re curious about what science can do, then you’re our kind of person.  

Cancer is one of the greatest challenges facing medical science today. In our Oncology Team, you’ll push the boundaries of science every day to overcome that challenge. We’ve been at the center of some of the biggest breakthroughs in oncology. In lung cancer, for example, we’ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. With a world-class pipeline and some of the best experts in the industry, we’re in a great position to develop even more innovative therapeutic approaches.

Main duties and responsibilities


   Immunotherapy is changing the paradigm for the treatment of cancer. Myeloid-targeting drugs have the potential to decrease immunosuppression in the tumor microenvironment (TME), thereby enhancing the activity of recently approved immune checkpoint blockade therapeutics. In this post-doctoral role, you will focus on characterizing the immune infiltrate in tumor models and clinical samples using cutting edge single cell sequencing techniques. By providing better understanding of the range of myeloid cell types in the TME and differentiating the effects of AstraZeneca’s myeloid targeting-drugs on the immune response, you will provide insights into how to best use these drugs in the clinical setting.  

   Your primary objectives will be to develop expertise in generating and interpreting single cell transcriptomic data; to characterize the breadth of myeloid/lymphoid cell subtypes in the TME +/- different drug treatments of mouse tumor models; and to extend this knowledge to clinical samples.  

   You’ll have the opportunity to work with leading academic labs to develop expertise in single cell sequencing approaches and also generate clinically relevant data. As a member of a highly motivated and experienced multidisciplinary Oncology team you’ll share our focus on publishing cutting edge research and bringing new medicines to cancer patients.  


   Essential requirements:  

  •      PhD and/or MD in relevant area of biology    
  •      Expertise with bioinformatic approaches to characterize heterogeneity and function in complex tissues based on RNASeq/transcriptomic data    
  •      Strong scientific background in immuno-oncology/immunology/myeloid biology    
  •      Strong publication track record    
  •      Familiarity with experimental design and execution of in vivo experiments to determine the effects of therapeutics on biological systems    
  •      Highly motivated, innovative and reliable with the ability to effectively solve problems    
  •      Flexible, collaborative and team-oriented mind set    
  •      Effective communication and presentation skills    
  •      Strong desire to learn and perform cancer research in an industry-academic collaborative setting.    

   To apply for this position, please click the apply link below.

   AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.  

   This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based. The role will be based at Waltham, MA with a competitive salary on offer. Please note if you have applied for this role previously, your application will still be considered, please do not re-apply.  

Opening date of advert: 3rd May 2017


Closing date of advert:  18th June 2017

   If you share our passion for scientific excellence, find out more at