The Ophthalmology Lead will manage the Ophthalmology functional group within the Discovery Research group under Translational Research. He/she will be responsible for:
Providing leadership within a group of 2 to 3 scientists/research associates, to develop pre-clinical programs from early discovery to the clinic.
Initiate and oversee joint programs with academic collaborators.
Establishing project timelines and ensuring work is completed according to schedule.
Training and developing staff at varying levels of experience.
The Ophtalmology Lead position requires extensive translational experience with ocular gene therapies, including:
In-depth familiarity with target validation and lead identification/optimization, using a combination of molecular, cellular and in vitro/in vivo techniques for ophthalmic gene therapy.
Familiar with intraocular delivery techniques and have substantial experience with ophthalmic studies in laboratory animals.
In-depth knowledge of inherited retinal disorders is required. Some familiarity with AAV, as well as some knowledge of clinical trial design and regulatory strategy, is preferred.
Hands-on execution of experiments on the bench
Identify and validate new indication targets. Design and trouble-shoot experiments based on personal experience and literature review. Prepare and deliver scientific presentations at internal and external meetings
Prioritize projects, plan workload, manage resource and personnel scheduling
Preparing sample analysis reports and write parts of regulatory submissions to FDA
Lead a team of scientists. Mentor and develop staff.
Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.
EDUCATION and EXPERIENCE REQUIREMENTS:
Ph.D. in relevant scientific discipline (e.g. cell and molecular biology, biochemistry, etc.)
Minimum 5-8 years of hands-on experience in the field of ophthalmic gene therapy
Previous management or supervisory experience strongly preferred
KEY SKILLS, ABILITIES and COMPETENCIES:
Extensive hands-on experience in ocular gene therapy, such as intravitreal and subretinal injections, pupillometry, etc.
Strong organizational skills.
Excellent writing and verbal communication skills.
Previous management experience preferred, but not required.
Strong publication record is a plus.
Experience with AAV vectors is a plus.
COMPLEXITY and PROBLEM SOLVING:
Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
Exercise judgment within defined procedures and practices to determine appropriate action.
INTERNAL and EXTERNAL CONTACTS:
Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Development, R&D Operations, Technical Operations, Regulatory Affairs, Executive Team.