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Molecular Biology Scientist

StemCells Inc.

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Location: Newark, CA Posted Date: 5/2/2013 Position Type: Full time Job Code: Scientist-BSP Required Education: Doctorate/PhD Areas of Expertise Desired: Cell Biology
Molecular Biology
Neurosciences

Description

StemCells, Inc. is engaged in the research, development, and commercialization of cell-based therapeutics and tools for use in stem cell-based research and drug discovery. The Company’s lead therapeutic product candidate, HuCNS-SC® cells (purified human neural stem cells), is currently in development as a potential treatment for a broad range of central nervous system disorders.  Clinical trials are underway in Spinal Cord Injury and dry Age-related Macular Degeneration.  StemCells also markets a range of stem cell research products under the SC Proven® brand, and offers contract cell process development and production services.

We are currently seeking a Molecular Biology Scientist who will further our research efforts utilizing solid molecular biology, analytical, and practical skills.

Responsibilities will include but not limited to:

• Participate in a team effort to characterize, and possibly alter, the properties and functionality of human tissue-derived neural stem cells in vitro and in vivo
• Develop gain- and loss-of-function (gene knockdown) experiments to validate surrogate markers of HuCNS-SC potencyUtilize gene constructs for stem cell potency or lineage specific differentiation in vitro and in vivo
• Develop improved/alternative protocols for donor cell detection based on HLA typing, utilizing qPCR and/or in-situ hybridization combined with lineage marker IHC for donor cell phenotype analysis
• Establish validated qPCR assay, based on specific molecular expression of a few markers (microarray analysis of early/late passage cells), as potency assay for HuCNS-SC engraftment/function
• Determine the best correlation with cellular function compared to other candidate direct biopotency and surrogate marker assays

StemCells, Inc. offers a comprehensive and competitive compensation package, as well as generous paid time off in addition to Company observed holidays, and Medical, Dental and Life Insurance. We promote a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork.  

For more information about StemCells, Inc., please visit http://www.stemcellsinc.com

To apply, please send your resume/CV to staffing@stemcellsinc.com, Subject: Scientist- BSP or FAX your resume/CV to: Staffing at (510) 456-4001.  No phone calls please.

Direct applicant only; no agencies, please.  EOE

Requirements

Candidate must possess:

• Ph.D. degree with 3-5 year experience in molecular and cell biology, ideally with a stem cell/neuroscience background
• Skilled in gene expression or reporter vector design / molecular cloning and use of relevant programs (e.g. Clone Manager), cellular transfection (lentiviral and electroporation), quantitative PCR, si/shRNA gene silencing, non-radioactive in-situ hybridization of tissue sections, and primary cell culture
• Excellent communication (written and oral) and organizational skills are required
• Must have a demonstrated ability to work effectively in a multidisciplinary- and team- oriented environment
• Stem cell or developmental neuroscience knowledge and experience is desirable, as is knowledge of HLA typing nomenclature, and experience with molecular biomarker assay development for clinical studies
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