Manufacturing Associate, Front-End - San Francisco, CA | Biospace
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Manufacturing Associate, Front-End

Twist Bioscience

San Francisco, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Associates Degree
Areas of Expertise Desired:
Manufacturing/Production, Operations,

Job Description

We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations Team in San Francisco. The Manufacturing Associate will be responsible for the manufacture of oligonucleotides for downstream processing and QC testing using Twist Bioscience’s proprietary process workflow and to meet the Twist production forecast and timelines.

The ideal candidate will be driven and will do what it takes to keep DNA synthesis manufacturing on track in a fast paced start-up environment. The Manufacturing Associate will produce oligos and perform QC testing on those oligos according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule. The ideal candidate will work independently, be very neat and organized, have basic knowledge and operation of equipment used in DNA synthesis, contribute to process improvement and documentation, and communicate effectively with peers and management. Knowledge of good laboratory practices (GLPs) is important. The Candidate must be comfortable working in a LEAN manufacturing/controlled laboratory environment.

Include but are not limited to:

Manufacture high quality custom gene products in a high throughput MFG lab according to established SOPs.
Maintain thorough, accurate and detailed documentation/databases of all work produced in batch records, databases or other acceptable formats  including problems and deviations.
Operation of automated equipment used to synthesize DNA
Operation of automated liquid handling equipment.
Familiar with DNA phosphoramidites and mixing with solvents
Moisture testing phosphoramidites
Keen observation and aptitude to proactively identify production problems/solutions, provide solutions on lab techniques, protocols, processes, handling of product and equipment
Upholding standards as defined by the manufacturing process.
Continuous improvement and good time management resulting in efficiency
Support cost improvement initiatives by reducing failures, improving capacity and using supplies wisely. Reduce work in process, queues and cycle times
Work in a safe manner
Maintenance and calibration of select lab equipment
Analytical characterization of DNA synthesis products
Include demonstrated knowledge and/or hands on experience with basic lab techniques and equipment/automation such as:

Team based laboratory environment
Working in controlled laboratory environment
Must be able to stand for long periods of time while performing duties
Must be able to work safely with chemicals and hazardous materials
Must be able to lift up to 40 lbs.
Must be able to work outside of regular work hours/ work a flexible shift as needed

SHIFT:  7PM-730 am shift 12h day/3d/4d alt work week with 1 weekend day. The incumbent will be required to work this night shift; the incumbent will start on day shift until training is complete before transitioning to night shift. Those who prefer day shifts should not apply.


Liquid handling
Experience with manual pipetting
Karl Fischer instrumentation
Oligonucleotide synthesis
Basic computer skills, especially with excel and MS Office products, statistics, JIRA, Confluence, SAP and MFG databases
Analytical Instruments:  Spectroscopy (Qubit, Nanodrop, plate reader), HPLC, CE ( BioAnalyzer, Fragment Analyzer)
Molecular biology or chemistry skills a plus

Some lab experience desired, preferably in MFG environment
Experience using equipment for DNA synthesis a plus
Ability to work in an ISO, GMP, LEAN, MFG environment and follow the lean manufacturing concepts
BA or BS in Biology or Chemistry a plus