Lead Scientist In Vivo Pharmacology - San Diego, CA | Biospace
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Lead Scientist In Vivo Pharmacology

Ambrx, Inc.

San Diego, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
In Vivo, Pharmacology, Scientist,

Job Description

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products.  Ambrx is seeking a highly motivated scientist to be a key member of a fast-paced and dynamic organization.  

The successful candidate is a hands on in vivo biologist and key member of the Pharmacology Department.  The position will support oncology targets in the rapidly expanding Antibody Drug Conjugate and Bi-specifics program.  The candidate will help to advance programs from early discovery to filing IND.


•   Lead and manage in house in vivo team to support the oncology pipeline
•   Manage external in vivo study activities through CROs and collaborators
•   Design, develop and execute disease model development and in vivo pharmacology studies (e.g., PK and efficacy)
•   Manage a vivarium core facility and Chair the Institutional Animal Care and Use Committee (IACUC)  
•   Write study plans/reports, monthly reports, and regulatory documents
•   Present data and communicate opinions effectively in project team meetings and collaborator meetings


?   Ph.D. in Biology, Pharmacology or a related scientific discipline with at least 6 years of pharmaceutical or biotech industry experience
?   Extensive hands-on experience in establishing oncology disease models and conducting in vivo efficacy/PD and PK studies
?   Experience in establishing and managing the vivarium and the IACUC
?   Experience in biologics drug development for cancer therapeutics
?   Experience in IND filing is a plus
?   Proven critical thinking, result interpretation, and systematic troubleshooting capability in the design and execution of scientific experiments  
?   Excellent oral/written communication and organizational skills are required
?   Ability to perform in a goal-oriented, fast-paced, matrixed team environment
?   Strong multi-tasking skills to handle multiple ongoing projects  

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code.  Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.  EOE