Head of Protein Engineering - Cambridge, MA | Biospace
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Head of Protein Engineering

Jounce Therapeutics

Cambridge, MA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:
Engineering, Protein,

Job Description

Based in Cambridge, Mass., Jounce is a company launched in 2013 with venture capital financing by Third Rock Ventures. In July 2016, we entered a global collaboration with Celgene focused on developing and commercializing innovative immuno-oncology treatments for patients with cancer. The funding from this partnership is helping to fuel our growth followed by an IPO in January 2017. We are looking for exceptional individuals who share our passion and perseverance for developing cancer immunotherapies that can dramatically impact and improve patients’ lives.

This role will guide efforts in the generation of biologic leads derived from discovery and optimization platforms for the development of novel therapeutics. The Head of Protein Engineering will manage a team of scientists in support of therapeutic programs focused in immuno-oncology. This role requires expertise in antibody engineering, biologic topologies, platform technologies, and developability assessment for lead candidate selection.


Essential Functions:

Provide strong leadership to a group of scientists in an environment of commitment to generate drugs that create transformative, long-lasting cancer immunotherapies
Lead discovery and protein engineering activities including helping devise best strategies to generate and optimize biologics for functional activity and manufacturability
Manage the design and implementation of technology development projects in the field of protein engineering
Work closely with Heads of Protein Production and Protein Analytics across multiple projects to support various discovery, preclinical, and translational efforts and ensure timelines and goals are met
In collaboration with other groups, oversee analysis and interpretation of data, disseminate key results and provide regular project status updates
Work closely with leaders in Discovery, Translational, and CMC to expedite development of candidates from Discovery to IND
Evaluate technology platforms for potential partnering or licensing opportunities


PhD in Biochemistry, Chemical Engineering, or related field
8+ yrs industry experience in antibody engineering with demonstrated expertise in biologic drug discovery and optimization including through use of novel protein engineering platforms
Experience with antibody technology platforms including hybridoma, transgenic hosts, and display platforms
Proven track record of leading, coaching and developing high functioning teams to engineer novel therapeutics from discovery to IND
Strong relationship building and communication skills to empower teams and leverage strengths
Effective management of CROs and technology platforms to deliver diverse panels of lead candidates for internal evaluation
Ability to work closely with leads across departments in Research to facilitate communication, transparency, efficient decision making and problem solving