Director, Translational Development (Protein Homeostasis) - San Diego, CA | Biospace
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Director, Translational Development (Protein Homeostasis)

Celgene

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Location:
San Diego, CA
Posted Date:
8/21/2017
Position Type:
Full time
Job Code:
17000481
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

Description

Celgene Research and Development

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.  Our discovery research teams are organized into thematic centers, each focused to certain areas of biology.  Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team.

Summary/Scope

The Celgene Protein Homeostasis Thematic Center is seeking a senior translational leader with the experience to define and implement preclinical and clinical translational strategies for novel agents entering clinical development, and a track record of success in this endeavor. Scientific depth and expertise in cancer biology and direct experience with clinical-stage correlative and translational support for novel agents are required.  This individual will play a leadership role in program strategy supporting dose and schedule, indication selection, patient selection, and PD samples and endpoints to inform and enable development of novel agents.  This is a management role with group leadership responsibility and potential for increasing organizational responsibility.    

This role will focus on agents targeting protein stability and function. Significant experience evaluating and applying technologies in genome, transcriptome, and proteome characterization to clinical samples, and demonstrated success in deriving novel biological information and insight into clinical outcomes from the resulting data, is required.

This position will require an individual with established scientific leadership ability and excellent communication and collaboration skills, and the ability to influence both inside and outside of Celgene.  A component of the role is identifying and leading key academic collaborations and CRO-based research, and managing these efforts to deliver impactful data.  As a leader of integrated discovery research and early development teams, this role will also involve collaboration with all essential functions (e.g. discovery biology and chemistry, toxicology, formulations, medical leads, computational biologists, and project management and leadership).

A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful.  We are particularly interested to hear from individuals with deep knowledge and skills in genetic and protein interaction networks and pathway dependencies. In particular, a knowledge of protein homeostasis pathways relevant to oncology would be helpful.  Specific expertise in hematology is a plus.

This position will report to the overall translational leader of the Protein Homeostasis Thematic center of Excellence, and will be located in San Diego, California.  Exceptional candidates who are geographically constrained to the San Francisco region may also be considered.

Key Responsibilities:

  • Translational science leader and manager in the context of early-phase clinical trials
  • Provide scientific leadership and management on cross-site and cross-functional teams
  • Lead group of translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data
  • Manage (directly and via direct and indirect reports) the selection, validation, and deployment of novel clinical-stage assay methods and analysis of data to accelerate development and provide insight into disease biology and drug mechanisms
  • Design and interpret experiments to define dose-schedules, patient selection markers and other biomarker readouts, combination strategies and pathways of drug resistance for oncology programs
  • Design and oversee execution of experiments to test hypotheses from clinical observations in preclinical model systems
  • Present key data at governance committees, internal forums, and external meetings
  • Author and oversee writing of study reports, patents, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards
  • Lead the identification, planning and execution of collaborative projects with leading academic and commercial research groups worldwide.
  • Management and hiring responsibility for translational scientists including direct and indirect reports up to the Sr. Principal Scientist/ Associate Director level.
  • Translational consultant and expert resource for programs within and also outside the Protein Homeostasis portfolio
  • Supervise contract research organizations to achieve high standards of productivity and quality.
  • Manage projects to successful outcomes through scientific leadership, teamwork and influence, and direct reporting relationships
  • Mentor research staff through instruction, coaching, and guidance
  • Work across geographies and scientific domains

Requirements

Qualifications

Prerequisites:

Ph.D. in a relevant field (Biology, Computational Biology, Biochemistry) with at least 18 years of relevant work experience, required.  Pharmaceutical industry experience is preferred.

Skills/Knowledge Required:

  • Expert in clinical translational studies including sampling, analysis, and interpretation of multiple data types including NGS/ omic data
  • Experienced translational leader able to define program priorities and strategies
  • Experienced and successful manager able to build and motivate teams, define goals and objectives, provide guidance and mentorship, negotiate conflicts, and optimize deployment of team resources to achieve objectives
  • Comprehensive knowledge of cancer biology and drug development
  • Proven ability to derive novel insights from complex data
  • Ability to interpret and summarize scientific data in an accurate, critical and concise manner
  • Strong understanding, derived from direct participation, of the design and execution of clinical trials incorporating translational science and correlative endpoints
  • Expertise in biomarker discovery and development, with advanced skills in assay design, development, validation, and troubleshooting
  • Experienced in the integration of preclinical research through to clinical drug development
  • Highly effective teamwork and interpersonal skills
  • Exceptional written and verbal communications skills.
  • Broad understanding of the R&D process.
  • Functional group advisor/go-to person.
  • Demonstrate broad understanding of Drug Discovery & Development.
  • Able to assess risk & develop contingency plans.
  • Recognized as expert in the field.
  • Serves as subject matter expert and functional group advisor on science, technology, methods, etc.
  • Familiar with basic business principles and focus of corporation.
  • Uses this knowledge to drive projects.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

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