Director/Senior Director, R&D CVMD Translational Medicine - Gaithersburg, MD | Biospace
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Director/Senior Director, R&D CVMD Translational Medicine

MedImmune, LLC

Gaithersburg, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

Gaithersburg, Maryland, United States
Job reference: R-011278
Posted date: Jul. 24, 2017

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Director (Grade 6)  or Senior Director (Grade 7), R&D CVMD Translational Medicine in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

As a dynamic thought leader in translational medicine to join the Translational Medicine ™ group within Translational Science at Medimmune, you will provide exceptional scientific and strategic leadership to understand molecular heterogeneity of Cardiovascular/Metabolic (CVMD) diseases, including diabetes, obesity, NASH, ACS, heart failure, and chronic kidney disease (CKD) and applying this knowledge to aid development of MedImmune’s exciting CVMD portfolio. Your primary responsibility will be to represent TM on the global project team for late stage molecules.  In addition, you will help lead a matrixed team of lab-enabled scientists / Sr. scientists and bioinformatics analysts to mine genomic and proteomic data from internal and external collaborations and clinical trials to develop high profile manuscripts and help establish scientific leadership for MedImmune in the areas of CVMD diseases.  You will also be expected to lead one or more Translational Science sub-teams that will apply knowledge derived from such analysis to develop testable personalized healthcare strategies. 

This is an important, high profile and visible role and you will be an individual with outstanding communication and leadership skills, as well as the ability to build strong relationships with key stakeholders in Clinical, other relevant functions within MedImmune, and external academic collaborators. You will be viewed as a strong scientific and strategic leader who can work with a fast-paced clinical and product development organization to translate fundamental insights into the molecular heterogeneity of CVMD diseases into targeted therapeutic and biomarker hypotheses that can be tested in clinical trials.   You will be expected to drive the publication of biomarker data in top-tier scientific, technical or medical journals.


Essential Requirements

For Director level:

  • MD, PhD/MD or PhD degree or equivalent experience in a relevant scientific field (e.g. molecular  biology, cell signaling bioinformatics)
  • Minimum 7 - 10 years post MD/PhD relevant experience in an academic or industry setting

For Senior Director level:

  • MD, PhD/MD or PhD degree or equivalent experience in a relevant scientific field (e.g. molecular biology, cell signaling, bioinformatics)
  • Minimum 10 – 13 years post MD/Ph.D. relevant experience in an academic or industry setting

For both roles:

  • Outstanding record of innovative contributions to translational sciences in CVMD diseases as evidenced by a strong publication record including first / senior-authored publications in top-tier journals, inventorship on crucial patents/filings and presentations at important conferences are a must for this role.
  • Experienced in analyzing large datasets including genomic and proteomic  together with a sound understanding of critical development functions, e.g. Clinical, Biomarker Development, Translational Medicine
  • Firm understanding of the molecular basis of human diseases in the CVMD space with a major focus in the MD area including diabetes, obesity, NASH, and chronic kidney disease.
  • In-depth knowledge of research and clinical development of biologic therapeutics.
Desirable Requirements
  • Familiarity with predictive biomarkers and personalized healthcare approaches as they pertain to research and early clinical development is highly desired.
  • Hands-on experience in development of in vitro and in vivo assays for clinical and research use, with the aim of assessing biomarkers for indication selection.
  • Understanding and ability to develop biomarker strategies and diagnostics to evaluate successful response to treatment with monoclonal antibody.
  • Familiarity with clinical protocols and regulatory processes.
  • Organizational skills with attention to detail and demonstrated ability to write technical reports, biomarker protocols, perform quantitative analyses, and graph and present data.
  • Outstanding verbal and written communication skills.
  • Strong leadership and interpersonal skills to work and lead in a matrix team environment.
  • Problem solving and organizational skills

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law