Director, Cell Biology and Assay Development - Brisbane, CA | Biospace
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Director, Cell Biology and Assay Development

Maverick Therapeutics

Brisbane, CA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

Maverick Therapeutics is a startup biotechnology company located in Brisbane, CA.  We are focused on the development of novel T-cell engaging biologics for oncology treatment. Maverick is looking for an energetic and highly motivated Director to lead our cell biology and assay development efforts and join our growing team.

Key responsibilities:
•   Lead antibody generation, screening, and characterization
1.   Establish and manage collaborations with CRO’s
2.   Characterize antibodies and bi-specifics in multiple binding assays (Octet, FACS, ELISA)
3.   Characterize antibodies and bi-specifics in functional assays (TDCC, cytokine production)
4.   Generate and characterize protein and cell-line reagents
•   Help to prioritize tumor antigens for antibody generation
•   Develop highly sensitive pharmacokinetic (PK) assays for preclinical and clinical studies
•   Participate in internal discussions to establish preclinical in vivo strategy, including study design proposals for mouse PK and efficacy studies and cyno PK and toxicology studies
•   Communicate scientific progress to management, advisors, and investors
•   Prioritize group’s efforts to align with and meet or exceed company goals and timelines
•   Recruit, train, manage, and retain high-value employees


The successful candidate will have a PhD in Cell Biology, Immunology or the like with >10 years industry experience in developing oncology biologics; will have expertise in program leadership in immuno-oncology and functional antibodies, target validation, antibody generation and screening, cell line generation and assay development.

Skills and qualifications:
•   >10 years industry program leadership and management experience in the development of oncology biologics, including:
1.   Leadership of cross-functional program teams for functional antibody, immuno-oncology, and CD3 bispecific programs
- Development and implementation of program strategy, including mouse tumor models, toxicology, and translational strategies to support regulatory filings
- Communication of program strategy and timelines to management
2.   Leadership of cross-site effort to prioritize tumor antigens for immuno-oncology bispecific therapeutics
3.   Development of pharmacokinetic, pharmacodynamic, and other biomarker assays, in collaboration with bioanalytics group
4.   Identification and validation of functional antibody targets on tumor cells
5.   Development of cell-based functional assays for antibody screening and characterization
6.   Establishment and management of academic and industry collaborations, resulting in publications
7.   Coaching and management of direct reports